Liu Fang-Xun, Wang Li, Yan Wen-Jie, Zou Li-Chun, Cao Yue-An, Lin Xiang-Chun
Department of International Medical Center, Peking University International Hospital, Beijing 102206, China.
Department of Gastroenterology, Peking University International Hospital, Beijing 102206, China.
World J Clin Cases. 2021 May 26;9(15):3586-3596. doi: 10.12998/wjcc.v9.i15.3586.
Research data from patient reports indicate that the least bearable part of colonoscopy is the administration of laxatives for bowel preparation.
To observe the intestinal cleansing efficacy and safety of sodium picosulfate/magnesium citrate and to discuss the patients' experiences due to the procedure.
Subjects hospitalized in the International Medical Center Ward of Peking University International Hospital, Beijing, China, from April 29 to October 29, 2020, for whom the colonoscopy was planned, were enrolled. Bowel preparation was performed using sodium picosulfate/magnesium citrate. The effect of bowel cleansing was evaluated according to the Ottawa Bowel Preparation Scale, defecation conditions and adverse reactions were recorded, and the comfort level and subjective satisfaction concerning medication were evaluated by the visual analogue scale/score (VAS).
The bowel preparation procedure was planned for all patients enrolled, which included 42 males and 22 females. The results showed an average liquid rehydration volume of 3000 mL, an average onset of action for the first dose at 89.04 min, an average number of bowel movements of 4.3 following the first dose, an average onset of action for the second dose at 38.90 min and an average number of bowel movements of 5.0 after the second dose. The total average Ottawa Bowel Preparation Scale score was 3.6, with 93.55% of bowel preparations in the "qualified" and 67.74% in the "excellent" grade. The average VAS score of effect on sleep was 0, and the average VAS score of perianal pain was also 0. The average VAS score for ease of taking and taste perception of the bowel cleanser was 10. Side effects included mild to moderate nausea (15.63%), mild vomiting (4.69%), mild to moderate abdominal pain (7.81%), mild to moderate abdominal distension (20.31%), mild palpitation (7.81%) and mild dizziness (4.69%).
Sodium picosulfate/magnesium citrate is effective and safe for bowel preparation before colonoscopy with high subjective patient acceptance, thus improving overall patient compliance.
来自患者报告的研究数据表明，结肠镜检查中最难以忍受的部分是用于肠道准备的泻药服用过程。
观察聚乙二醇4000/枸橼酸镁的肠道清洁效果和安全性，并探讨患者在该过程中的体验。
纳入2020年4月29日至10月29日在中国北京北京大学国际医院国际医疗中心病房住院且计划进行结肠镜检查的患者。采用聚乙二醇4000/枸橼酸镁进行肠道准备。根据渥太华肠道准备量表评估肠道清洁效果，记录排便情况和不良反应，并通过视觉模拟量表/评分（VAS）评估用药的舒适度和主观满意度。
所有纳入患者均按计划进行了肠道准备，其中男性42例，女性22例。结果显示，平均补液量为3000 mL，首剂平均起效时间为89.04分钟，首剂后平均排便次数为4.3次，第二剂平均起效时间为38.90分钟，第二剂后平均排便次数为5.0次。渥太华肠道准备量表总平均分是3.6分，93.55%的肠道准备为“合格”，67.74%为“优秀”等级。对睡眠影响的平均VAS评分为0，肛周疼痛的平均VAS评分也为0。肠道清洁剂服用便利性和口感的平均VAS评分为10分。副作用包括轻度至中度恶心（15.63%）、轻度呕吐（4.69%）、轻度至中度腹痛（7.81%）、轻度至中度腹胀（20.31%）、轻度心悸（7.81%）和轻度头晕（4.69%）。
聚乙二醇4000/枸橼酸镁在结肠镜检查前用于肠道准备有效且安全，患者主观接受度高，从而提高了患者的总体依从性。
