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本文引用的文献

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Covalent inhibitors: a rational approach to drug discovery.共价抑制剂：药物发现的合理方法。
RSC Med Chem. 2020 Jul 2;11(8):876-884. doi: 10.1039/d0md00154f. eCollection 2020 Aug 1.
2
Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.乙酰辅酶 A 介导激活结核分枝杆菌异柠檬酸裂解酶 2。
Nat Commun. 2019 Oct 11;10(1):4639. doi: 10.1038/s41467-019-12614-7.
3
Sweetly profiling the cysteinome.巧妙描绘半胱氨酸组。
Nat Chem Biol. 2019 Oct;15(10):935-936. doi: 10.1038/s41589-019-0348-9.
4
S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate.基于 S-糖基化的半胱氨酸分析揭示了衣康酸对糖酵解的调控作用。
Nat Chem Biol. 2019 Oct;15(10):983-991. doi: 10.1038/s41589-019-0323-5. Epub 2019 Jul 22.
5
Applications of Ensemble Docking in Potential Inhibitor Screening for Mycobacterium tuberculosis Isocitrate Lyase Using a Local Plant Database.基于局部植物数据库的组合对接在结核分枝杆菌异柠檬酸裂解酶潜在抑制剂筛选中的应用。
J Chem Inf Model. 2019 May 28;59(5):2487-2495. doi: 10.1021/acs.jcim.8b00963. Epub 2019 Mar 14.
6
Itaconate: the poster child of metabolic reprogramming in macrophage function.异柠檬酸：巨噬细胞功能代谢重编程的典型代表。
Nat Rev Immunol. 2019 May;19(5):273-281. doi: 10.1038/s41577-019-0128-5.
7
Development of NMR and thermal shift assays for the evaluation of isocitrate lyase inhibitors.用于评估异柠檬酸裂解酶抑制剂的核磁共振和热位移分析方法的开发。
Medchemcomm. 2017 Oct 17;8(11):2155-2163. doi: 10.1039/c7md00456g. eCollection 2017 Nov 1.
8
The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition.硝基集团作为共价酶抑制中的掩蔽亲电试剂。
ACS Chem Biol. 2018 Jun 15;13(6):1470-1473. doi: 10.1021/acschembio.8b00225. Epub 2018 May 23.
9
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.衣康酸及其衍生物的亲电性调节 IκBζ-ATF3 炎症轴。
Nature. 2018 Apr;556(7702):501-504. doi: 10.1038/s41586-018-0052-z. Epub 2018 Apr 18.
10
Structure-based design of targeted covalent inhibitors.基于结构的靶向共价抑制剂设计。
Chem Soc Rev. 2018 Jun 5;47(11):3816-3830. doi: 10.1039/c7cs00220c.

衣康酸是异柠檬酸裂解酶的共价抑制剂。

Itaconate is a covalent inhibitor of the isocitrate lyase.

作者信息

Kwai Brooke X C, Collins Annabelle J, Middleditch Martin J, Sperry Jonathan, Bashiri Ghader, Leung Ivanhoe K H

机构信息

School of Chemical Sciences, The University of Auckland Private Bag 92019, Victoria Street West Auckland 1142 New Zealand

School of Biological Sciences, The University of Auckland Private Bag 92019, Victoria Street West Auckland 1142 New Zealand

出版信息

RSC Med Chem. 2020 Oct 19;12(1):57-61. doi: 10.1039/d0md00301h. eCollection 2021 Jan 1.

DOI:10.1039/d0md00301h
PMID:34046597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8130629/
Abstract

Itaconate is a mammalian antimicrobial metabolite that inhibits the isocitrate lyases (ICLs) of . Herein, we report that ICLs form a covalent adduct with itaconate through their catalytic cysteine residue. These results reveal atomic details of itaconate inhibition and provide insights into the catalytic mechanism of ICLs.

摘要

衣康酸是一种哺乳动物抗菌代谢产物，可抑制[具体生物]的异柠檬酸裂解酶（ICL）。在此，我们报告ICL通过其催化性半胱氨酸残基与衣康酸形成共价加合物。这些结果揭示了衣康酸抑制作用的原子细节，并为ICL的催化机制提供了见解。