Arce-McShane Fritzie I
Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street (Anatomy Suite 303),Chicago, IL 60637, USA.
Adv Geriatr Med Res. 2021;3(2). doi: 10.20900/agmr20210011. Epub 2021 Apr 27.
The global population of 80 years and older is predicted to reach 437 million by 2050. As overall brain structure and function progressively degrades, older and younger adults show differences in sensorimotor performance and brain activity in the sensorimotor regions. Oral sensorimotor functions are an important area of focus in natural aging and Alzheimer's Disease (AD) because oral health issues are commonly found in both elderly and AD populations. While human behavioral studies on changes in oral sensorimotor functions abound, very little is known about their neuronal correlates in normal and pathological aging.
预计到2050年，全球80岁及以上的人口将达到4.37亿。随着大脑整体结构和功能逐渐退化，老年人和年轻人在感觉运动表现以及感觉运动区域的大脑活动方面存在差异。口腔感觉运动功能是自然衰老和阿尔茨海默病（AD）研究的一个重要重点领域，因为口腔健康问题在老年人群和AD患者中都很常见。虽然关于口腔感觉运动功能变化的人类行为学研究很多，但对于其在正常衰老和病理性衰老过程中的神经相关性却知之甚少。
