Department of infectious diseases, Klinik Favoriten, Kundratstraße 3, 1100, Vienna, Austria.
Wien Klin Wochenschr. 2021 Jul;133(13-14):724-726. doi: 10.1007/s00508-021-01877-0. Epub 2021 May 27.
Flavonifractor plautii is a gram-positive, strictly anaerobic, rod-shaped bacterium. It belongs to the family of Clostridiales, is frequently found in the human gut microbiome and is rarely isolated in other human specimens.
We report a case of a bloodstream infection with Flavonifractor plautii following infectious colitis in a 24-year-old asplenic woman with beta thalassemia. The patient presented to our department with diarrhea, fever, and lower abdominal pain for over 1 month. F. plautii was the only organism isolated from blood cultures.
The antimicrobial resistance pattern showed in vitro sensitivity to all antimicrobials used for treatment; however, in vivo treatment with amoxicillin and clavulanic acid failed. After switching to meropenem and metronidazole the patient rapidly recovered.
Asplenia and a damaged intestinal wall might have favored the bloodstream infection. We found similarities in attributes of the affected patients and in treatment patterns between our case and the only three other published case reports.
普雷沃氏菌（Flavonifractor plautii）是一种革兰氏阳性、严格厌氧的杆状细菌。它属于梭菌科，经常存在于人类肠道微生物组中，很少在其他人类标本中分离出来。
我们报告了一例因感染性结肠炎导致脾切除的β地中海贫血 24 岁女性血流感染普雷沃氏菌（Flavonifractor plautii）的病例。该患者因腹泻、发热和下腹痛超过 1 个月就诊于我院。血液培养仅分离出普雷沃氏菌（Flavonifractor plautii）。
体外药敏试验显示该菌对所有用于治疗的抗菌药物均敏感，但体内应用阿莫西林克拉维酸治疗失败。换用美罗培南和甲硝唑后，患者迅速康复。
脾切除和受损的肠壁可能有利于血流感染。我们发现，我们的病例与仅有的三例已发表的病例报告中的患者的特征和治疗模式存在相似之处。
