Zamora Diaz David, Llanes Somellera Sergio
Internal Medicine, Loyola University Medical Center, Berwyn, USA.
Cureus. 2025 Jun 21;17(6):e86478. doi: 10.7759/cureus.86478. eCollection 2025 Jun.
(formerly ) is a Gram-variable, strict anaerobic bacillus that forms part of the human gut microbiome, although its role in human health remains incompletely understood. has rarely been linked to clinical infections. We describe a case of bacteremia in a patient with severe intrahepatic biliary ductal dilatation and septic shock and bacteremia, which cleared following treatment with ceftriaxone and metronidazole. Diarrhea with disruption of the gut barrier and subsequent bacterial translocation appear to be the mechanism for bacteremia due to this organism. Based on this case and previous reports, infections appear susceptible to beta-lactam antibiotics (e.g., ampicillin, ceftriaxone) and anaerobic agents (e.g., metronidazole, clindamycin), supporting their use as preferred treatment options over glycopeptides or oxazolidinones. This case underscores the importance of recognizing anaerobic gut commensals as potential bloodstream pathogens in critically ill patients.
（以前）是一种革兰氏染色不定的严格厌氧芽孢杆菌，它是人类肠道微生物群的一部分，尽管其在人类健康中的作用仍未完全了解。很少与临床感染相关。我们描述了一例患有严重肝内胆管扩张和感染性休克以及菌血症的患者，经头孢曲松和甲硝唑治疗后菌血症得以清除。肠道屏障破坏导致的腹泻及随后的细菌易位似乎是该菌导致菌血症的机制。基于此病例及先前报道，感染似乎对β-内酰胺类抗生素（如氨苄西林、头孢曲松）和厌氧制剂（如甲硝唑、克林霉素）敏感，这支持将它们作为优于糖肽类或恶唑烷酮类的首选治疗选择。该病例强调了认识到厌氧性肠道共生菌作为重症患者潜在血流病原体的重要性。
