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特发性颅内高压的结局指标

Outcomes measures in idiopathic intracranial hypertension.

作者信息

Mollan Susan P, Sinclair Alexandra J

机构信息

Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, Birmingham, United Kingdom (UK).

Metabolic Neurology, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

出版信息

Expert Rev Neurother. 2021 Jun;21(6):687-700. doi: 10.1080/14737175.2021.1931127. Epub 2021 Jun 7.

Abstract

: Idiopathic intracranial hypertension is a condition characterized by raised intracranial pressure, papilledema, and normal neuroimaging (aside from radiological signs of raised intracranial pressure). Symptoms of idiopathic intracranial hypertension include chronic headaches and for some, visual loss. New treatments are unmet clinical needs.: The aim of this review is to present the evidence base and considered opinion on outcome measures to determine successful management of idiopathic intracranial hypertension.: Less invasive measures of disease activity such as optical coherence tomography will continue to grow in this field, both as a measure of papilledema, and potentially as a surrogate for intracranial pressure and visual function. As a highly disabling aspect of the disease is headache, treatment outcomes for headache morbidity need to be appropriately chosen and standardized to allow comparison between trials.

摘要

特发性颅内高压是一种以颅内压升高、视乳头水肿和正常神经影像学表现(除颅内压升高的放射学征象外)为特征的疾病。特发性颅内高压的症状包括慢性头痛,对一些人来说还包括视力丧失。新的治疗方法是未满足的临床需求。

本综述的目的是提供证据基础,并对确定特发性颅内高压成功治疗的结局指标发表深思熟虑的意见。

疾病活动度的侵入性较小的测量方法,如光学相干断层扫描,在该领域将继续发展,既作为视乳头水肿的一种测量方法,也可能作为颅内压和视觉功能的替代指标。由于该疾病的一个严重致残方面是头痛,头痛发病率的治疗结局需要适当选择并标准化,以便在试验之间进行比较。

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