Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Curr Top Med Chem. 2021;21(28):2514-2528. doi: 10.2174/1568026621666210527103225.
Imidazole has an important five-membered aromatic heterocyclic ring, which is available widely in natural products and synthetic molecules. The special structural characteristics of imidazole ring enable it to bind with a variety of enzymes and receptors through hydrogen bonds, coordination, ion-dipole and cation-π interactions, hydrophobic effects, and Van der Waals forces. These interactions promote several biological activities involving anti-tumor, anti-inflammatory, anti-microbial, and anti-viral properties. Herein, we review and discuss recent developments in using imidazole derivatives and their special pharmacological activities for the treatment of various diseases.
咪唑具有重要的五元芳香杂环，广泛存在于天然产物和合成分子中。咪唑环的特殊结构特征使其能够通过氢键、配位、离子偶极和阳离子-π 相互作用、疏水作用和范德华力与各种酶和受体结合。这些相互作用促进了几种涉及抗肿瘤、抗炎、抗菌和抗病毒特性的生物活性。本文综述和讨论了使用咪唑衍生物及其特殊药理学活性治疗各种疾病的最新进展。
