School of Sciences, P P Savani University, NH 8, GETCO, Near Biltech, Dhamdod, Kosamba, Surat 394125, Gujarat, India.
Department of Physics, Faculty of Sciences, University 20 Août 1955 Skikda, Skikda 21000, Algeria.
Molecules. 2023 Jul 18;28(14):5490. doi: 10.3390/molecules28145490.
Heterocyclic compounds are significant lead drug candidates based on their various structure-activity relationships (SAR), and their use in pharmaceutics is constantly developing. Benzimidazole (BnZ) is synthesized by a condensation reaction between benzene and imidazole. The BnZ structure consists of two nitrogen atoms embedded in a five-membered imide ring which is fused with a benzene ring. This review examines the conventional and green synthesis of metallic and non-metallic BnZ and their derivatives, which have several potential SARs, along with a wide range of pharmacological properties, including anti-cancer, anti-inflammatory, anti-microbial, anti-tubercular, and anti-protozoal properties. These compounds have been proven by pharmacological investigations to be efficient against different strains of microbes. Therefore, in this review, the structural variations of BnZ are listed along with various applications, predominantly related to their biological activities.
杂环化合物因其各种结构-活性关系（SAR）而成为重要的药物先导候选物，其在药剂学中的应用也在不断发展。苯并咪唑（BnZ）是通过苯和咪唑之间的缩合反应合成的。BnZ 结构由嵌入在五元酰亚胺环中的两个氮原子组成，该环与苯环融合。本综述考察了金属和非金属 BnZ 及其衍生物的常规和绿色合成，这些化合物具有多种潜在的 SAR，以及广泛的药理学特性，包括抗癌、抗炎、抗菌、抗结核和抗原生动物特性。这些化合物已通过药理学研究证明对不同菌株的微生物有效。因此，在本综述中，列出了 BnZ 的结构变化及其各种应用，主要与它们的生物活性有关。
