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Preliminary analyses of scRNA sequencing and immunohistochemistry of children's lung tissues indicate the expression of SARS-CoV-2 entry-related genes may not be the key reason for the milder syndromes of COVID-19 in children.

作者信息

Tao Yue, Yang Ruwen, Wen Chen, Fan Jue, Ma Jing, He Qiao, Zhao Zhiguang, Song Xinyu, Chen Hao, Shi Guocheng, Yin Minzhi, Fang Nan, Zhang Hao, Chen Huiwen, Mo Xi

机构信息

The Laboratory of Pediatric Infectious Diseases, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

出版信息

Clin Transl Med. 2021 May;11(5):e300. doi: 10.1002/ctm2.300.

DOI:10.1002/ctm2.300
PMID:34047474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8140187/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/8140187/65f016203c75/CTM2-11-e300-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/8140187/338836694729/CTM2-11-e300-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/8140187/65f016203c75/CTM2-11-e300-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/8140187/338836694729/CTM2-11-e300-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e1d/8140187/65f016203c75/CTM2-11-e300-g001.jpg

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Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study.英国因 COVID-19 住院的儿童和青少年的临床特征：前瞻性多中心观察队列研究。
BMJ. 2020 Aug 27;370:m3249. doi: 10.1136/bmj.m3249.
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Single-cell transcriptomic atlas of primate cardiopulmonary aging.灵长类心肺衰老的单细胞转录组图谱。
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Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study.
严重急性呼吸综合征冠状病毒2利用气道上皮保护机制进行病毒感染。
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Projecting the SARS-CoV-2 transition from pandemicity to endemicity: Epidemiological and immunological considerations.预测 SARS-CoV-2 从大流行向地方病的转变：流行病学和免疫学方面的考虑。
PLoS Pathog. 2022 Jun 30;18(6):e1010591. doi: 10.1371/journal.ppat.1010591. eCollection 2022 Jun.
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Effect of age on human ACE2 and ACE2-expressing alveolar type II cells levels.年龄对人血管紧张素转换酶 2（ACE2）和 ACE2 表达的肺泡Ⅱ型细胞水平的影响。
Pediatr Res. 2023 Mar;93(4):948-952. doi: 10.1038/s41390-022-02163-z. Epub 2022 Jun 23.
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Age-related differences in SARS-CoV-2 binding factors: An explanation for reduced susceptibility to severe COVID-19 among children?年龄相关的 SARS-CoV-2 结合因子差异：儿童对严重 COVID-19 易感性降低的解释？
Paediatr Respir Rev. 2022 Dec;44:61-69. doi: 10.1016/j.prrv.2022.01.008. Epub 2022 Feb 8.
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Exp Physiol. 2022 Jul;107(7):653-664. doi: 10.1113/EP089399. Epub 2021 Aug 5.
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Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
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Evolution of the immune system in humans from infancy to old age.人类免疫系统从婴儿期到老年期的演变。
Proc Biol Sci. 2015 Dec 22;282(1821):20143085. doi: 10.1098/rspb.2014.3085.
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Life Sci. 2006 Apr 4;78(19):2166-71. doi: 10.1016/j.lfs.2005.09.038. Epub 2005 Nov 21.
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Pediatrics. 1977 Oct;60(4):467-72.