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坏死性小肠结肠炎小鼠模型。

A Mouse Model of Necrotizing Enterocolitis.

机构信息

Division of Newborn Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO, USA.

出版信息

Methods Mol Biol. 2021;2321:101-110. doi: 10.1007/978-1-0716-1488-4_9.

Abstract

Necrotizing enterocolitis (NEC) is an acute inflammatory disease that unforeseeably develops in very low birth weight premature infants. NEC is characterized by impairment of the intestinal barrier resulting in intestinal necrosis and multisystem organ failure. Animal models of NEC have contributed significantly to a better understanding of the underlying molecular mechanisms of the disease and facilitated the exploration of potential new therapeutic strategies. Here, we provide a detailed protocol that recapitulates some of the main histological and transcriptional features of human NEC in newborn mice.

摘要

坏死性小肠结肠炎(NEC)是一种在极低出生体重早产儿中不可预测发生的急性炎症性疾病。NEC 的特征是肠道屏障受损,导致肠坏死和多器官功能衰竭。NEC 的动物模型极大地促进了对疾病潜在分子机制的更好理解,并为探索潜在的新治疗策略提供了便利。在这里,我们提供了一个详细的方案,该方案再现了新生小鼠中一些与人 NEC 相关的主要组织学和转录特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/70c8/8272439/8a1e0405bea7/nihms-1717030-f0001.jpg

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