Jin Seung-Woo, Lee Inah
Department of Brain and Cognitive Sciences, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, Korea.
Department of Brain and Cognitive Sciences, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, Korea.
Curr Biol. 2021 Jul 26;31(14):3053-3072.e5. doi: 10.1016/j.cub.2021.04.073. Epub 2021 May 27.
It is widely held that the hippocampus provides a cognitive map in which event-related information, such as an object, location, and their significance, is organized. However, how an organism's motivational experience is coded in the hippocampus is mostly unknown. Here, we investigated whether dorsal and intermediate regions of the hippocampus are differentially involved in representing changes in the motivational significance of a place. Rats were run in tasks in which various rewards with different degrees of palatability were associated with the same locations while single units were simultaneously recorded along the dorsoventral axis of the hippocampus. Place cells in the intermediate hippocampus remapped immediately after motivational significance decreased and shifted their fields dynamically toward high-value locations. In contrast, place cells in the dorsal hippocampus were mostly unresponsive to the same manipulations. Our findings suggest that the motivational significance of place is uniquely coded in the intermediate hippocampus in goal-directed tasks.
人们普遍认为，海马体提供了一种认知地图，其中与事件相关的信息，如物体、位置及其重要性，都被组织起来。然而，生物体的动机体验如何在海马体中编码，大多仍不为人知。在这里，我们研究了海马体的背侧和中间区域是否在表征地点动机重要性的变化中发挥不同作用。我们让大鼠执行任务，在这些任务中，不同可口程度的各种奖励与相同的位置相关联，同时沿着海马体的背腹轴同步记录单个神经元。动机重要性降低后，中间海马体中的位置细胞立即重新映射，并将其活动区域动态地转向高价值位置。相比之下，背侧海马体中的位置细胞对相同的操作大多没有反应。我们的研究结果表明，在目标导向任务中，地点的动机重要性在中间海马体中被独特地编码。
