Department of Neurology, the Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Department of Surgery Spine, the Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
BMC Neurol. 2021 May 28;21(1):212. doi: 10.1186/s12883-021-02245-1.
Graves' disease and anti-GQ1b antibody syndrome are both autoimmune diseases, and there have been few reports on whether there is a correlation between the two. In this study, we present the case of a woman who was diagnosed with Graves' disease and anti-GQ1b antibody syndrome in succession.
The chief complaints of this patient were limb weakness and blurred vision. Graves' disease was diagnosed by examination of thyroid function and thyroid autoantibodies, but the clinical symptoms were not relieved after antihyperthyroidism treatment. Finally, it was found that Graves' disease was complicated by anti-GQ1b antibody syndrome, and the symptoms were relieved after treatment with glucocorticoids and intravenous immunoglobulin. We also explored the possible mechanism of these diseases through a literature review.
We report a rare case of the cooccurrence of Graves' disease and anti-GQ1b antibody syndrome. Immune dysregulation might be the pathogenesis of the association, but there is no precise supporting evidence, and more research is needed.
格雷夫斯病和抗-GQ1b 抗体综合征都是自身免疫性疾病，关于两者之间是否存在关联，鲜有报道。本研究报告了一例先后被诊断为格雷夫斯病和抗-GQ1b 抗体综合征的女性病例。
该患者的主要主诉为四肢无力和视力模糊。通过甲状腺功能和甲状腺自身抗体检查诊断为格雷夫斯病，但抗甲状腺功能亢进治疗后临床症状并未缓解。最终发现格雷夫斯病并发抗-GQ1b 抗体综合征，经糖皮质激素和静脉注射免疫球蛋白治疗后症状缓解。我们还通过文献回顾探讨了这些疾病的可能发病机制。
我们报告了一例罕见的格雷夫斯病和抗-GQ1b 抗体综合征合并病例。免疫失调可能是两者相关的发病机制，但目前尚无确切的支持证据，需要进一步研究。
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