Department of Cellular Physiology and Metabolism, University of Geneva, Geneva, Switzerland.
Prog Mol Subcell Biol. 2021;59:51-97. doi: 10.1007/978-3-030-67696-4_4.
The endoplasmic reticulum (ER) Ca sensor stromal interaction molecule 1 (STIM1) interacts with ORAI Ca channels at the plasma membrane to regulate immune and muscle cell function. The conformational changes underlying STIM1 activation, translocation, and ORAI1 trapping and gating, are stringently regulated by post-translational modifications and accessory proteins. Here, we review the recent progress in the identification and characterization of ER and cytosolic proteins interacting with STIM1 to control its activation and deactivation during store-operated Ca entry (SOCE).
内质网（ER）Ca 传感器基质相互作用分子 1（STIM1）与质膜上的 ORAI Ca 通道相互作用，调节免疫和肌肉细胞功能。STIM1 激活、易位以及 ORAI1 捕获和门控的构象变化受到翻译后修饰和辅助蛋白的严格调控。本文综述了近年来鉴定和表征与 STIM1 相互作用的 ER 和胞质蛋白的研究进展，这些蛋白在储存操纵的 Ca 内流（SOCE）过程中控制 STIM1 的激活和失活。
