Unal Mustafa, Aksoy Duygu Yazgan, Aydın Yusuf, Tanriover Mine Durusu, Berker Dilek, Karakaya Jale, Guler Serdar
Department of Endocrinology and Metabolism, Numune Research and Training Hospital, Ankara, Turkey.
epartment of Endocrinology and Metabolism, Numune Research and Training Hospital, Ankara, Turkey.
Med Sci Monit. 2014 May 29;20:884-8. doi: 10.12659/MSM.889771.
Metabolic syndrome (MS) has become a pandemic in Turkey, as is the case globally. Increase in carotid artery intima-media thickness (CIMT) and erectile dysfunction (ED) may be evident before the clinical signs of cardiovascular disease appear. We aimed to investigate the prevalence of increased CIMT and ED as markers of atherosclerotic disease in patients with MS.
Thirty-two patients with MS and 29 healthy controls were included. Anthropometric and biochemical parameters, along with total testosterone (TT), high sensitive C-reactive protein (hs-CRP), were recorded. Carotid artery intima-media thickness was measured. Erectile dysfunction was assessed with International Index of Erectile Function.
Patients with MS had higher BMI, fasting plasma glucose, post-prandial plasma glucose, insulin, HOMA-IR, total cholesterol, triglycerides, hs-CRP, and CIMT, whereas TT levels were lower (p<0.0001). The prevalence and severity of erectile dysfunction were higher in patients with MS (p<0.0001). Erectile dysfunction scores correlated inversely with CIMT. MS patients with ED were older and had higher CIMT compared to those without ED. Increase in age and HOMA and decrease in TT increased the risk of ED. When KIMT exceeding the 95th percentile of healthy controls was accepted as a risk factor for CVD, presence of ED was the only determinant for this increase.
Erectile dysfunction was more prevalent and severe in patients with MS and correlated with subclinical endothelial dysfunction. Total testosterone deficiency was prominent among MS patients. Presence of ED points to an increased risk of cardiovascular disease when MS is present.
代谢综合征（MS）在土耳其已成为一种流行病，全球情况亦是如此。在心血管疾病临床症状出现之前，颈动脉内膜中层厚度（CIMT）增加和勃起功能障碍（ED）可能就已很明显。我们旨在调查MS患者中CIMT增加和ED作为动脉粥样硬化疾病标志物的患病率。
纳入32例MS患者和29例健康对照者。记录人体测量和生化参数，以及总睾酮（TT）、高敏C反应蛋白（hs-CRP）。测量颈动脉内膜中层厚度。采用国际勃起功能指数评估勃起功能障碍。
MS患者的体重指数、空腹血糖、餐后血糖、胰岛素、HOMA-IR、总胆固醇、甘油三酯、hs-CRP和CIMT较高，而TT水平较低（p<0.0001）。MS患者勃起功能障碍的患病率和严重程度更高（p<0.0001）。勃起功能障碍评分与CIMT呈负相关。与无ED的MS患者相比，有ED的MS患者年龄更大，CIMT更高。年龄增加、HOMA增加和TT降低会增加ED风险。当将超过健康对照者第95百分位数的KIMT视为心血管疾病的危险因素时，ED的存在是这种增加的唯一决定因素。
勃起功能障碍在MS患者中更普遍且更严重，并且与亚临床内皮功能障碍相关。MS患者中总睾酮缺乏较为突出。当存在MS时，ED的存在表明心血管疾病风险增加。
