Suzhou Medical College of Soochow University, Suzhou, China.
Department of Urology, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Front Endocrinol (Lausanne). 2022 Oct 6;13:1027430. doi: 10.3389/fendo.2022.1027430. eCollection 2022.
Our goal is to investigate the connection between serum 25(OH)D and carotid artery intima-media thickness (CIMT) in men with erectile dysfunction (ED).Serum 25(OH)D and CIMT were measured in 124 participants with erectile dysfunction and 39 healthy controls. The relationship between them and different patient-related parameters and disease-related parameters was studied. Compared with the control group and mild ED group, the level of serum 25(OH)D in moderate ED group and severe ED group decreased significantly(<0.05). The CIMT values of moderate ED group and severe ED group were higher than those of the control group(<0.05). The CIMT value of severe ED group was significantly higher than that of mild ED group(<0.05). IIEF-5 score was positively correlated with serum 25(OH)D level, but negatively correlated with CIMT value(<0.05). After adjusting for the influence of confounding factors, The CIMT values, 25(OH)D and IIEF-5 score were substantially associated(<0.05). The serum level of 25(OH)D and IIEF-5 score were positively correlated, while the CIMT values and IIEF-5 score were negatively correlated. The level of serum 25(OH)D should be analyzed in men with ED, especially in patients with vasculogenic ED, and supplementation is recommended for those who were with vitamin D deficiency.
我们的目的是研究血清 25（OH）D 与男性勃起功能障碍（ED）患者颈动脉内膜中层厚度（CIMT）之间的关系。在 124 名勃起功能障碍患者和 39 名健康对照者中测量了血清 25（OH）D 和 CIMT。研究了它们与不同的患者相关参数和疾病相关参数之间的关系。与对照组和轻度 ED 组相比，中度 ED 组和重度 ED 组的血清 25（OH）D 水平显著降低（<0.05）。中度 ED 组和重度 ED 组的 CIMT 值高于对照组（<0.05）。重度 ED 组的 CIMT 值明显高于轻度 ED 组（<0.05）。IIEF-5 评分与血清 25（OH）D 水平呈正相关，与 CIMT 值呈负相关（<0.05）。在调整了混杂因素的影响后，CIMT 值、25（OH）D 和 IIEF-5 评分之间存在显著相关性（<0.05）。血清 25（OH）D 水平与 IIEF-5 评分呈正相关，而 CIMT 值与 IIEF-5 评分呈负相关。ED 患者应分析血清 25（OH）D 水平，尤其是血管性 ED 患者，建议对维生素 D 缺乏者进行补充。
