Institut für Radiopharmazeutische Krebsforschung, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, D-01328 Dresden, Germany.
Institut für Radiopharmazeutische Krebsforschung, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstraße 400, D-01328 Dresden, Germany.
Nucl Med Biol. 2021 Jul-Aug;98-99:59-68. doi: 10.1016/j.nucmedbio.2021.05.003. Epub 2021 May 16.
With the exception of beryllium, divalent cations of every alkaline earth metal are characterized by their calcimimetic behavior. Thus, in vivo biodistribution of these cations mostly occurs in form of a massive accumulation in bone tissues, consisting of hydroxyapatite to a major extent. Apart from the lightest elements beryllium and magnesium, animal studies and human studies regarding the overall in vivo behavior were carried out by using radioisotopes of the elements calcium, strontium, barium and radium. To date, only strontium with its radioisotopes and radium gained importance for applications in nuclear medicine, mainly for pain-reducing and palliative treatment of bone metastases. In contrast, barium radioisotopes can be ascertained as useful imaging agents and possible diagnostic analogues for theranostic approaches. This review focuses on the characteristic and chemical behavior of barium compounds, possible radioactive barium isotopes for future applications in nuclear medicine and radiopharmacy as well as recent results regarding barium-131 as diagnostic match for radium isotopes used in targeted alpha therapy.
除铍之外，所有碱土金属的二价阳离子都具有类似钙的性质。因此，这些阳离子在体内的生物分布主要以大量形式存在于骨组织中，主要由羟磷灰石组成。除了最轻的铍和镁元素外，动物研究和人类研究都是通过钙、锶、钡和镭这些元素的放射性同位素来进行的。迄今为止，只有锶及其放射性同位素和镭在核医学应用中获得了重要性，主要用于减轻疼痛和姑息治疗骨转移。相比之下，钡的放射性同位素可以作为有用的成像剂和治疗诊断方法的可能的诊断类似物。本文综述了钡化合物的特性和化学行为，以及未来在核医学和放射药物学中可能应用的放射性钡同位素，以及最近关于钡-131 作为靶向 alpha 治疗中使用的镭同位素的诊断匹配物的研究结果。
