Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd, Pasadena, 91125, CA, USA.
Division of Biology and Biological Engineering, California Institute of Technology, 1200 E California Blvd, Pasadena, 91125, CA, USA.
Curr Opin Chem Biol. 2021 Dec;65:18-27. doi: 10.1016/j.cbpa.2021.04.004. Epub 2021 May 26.
Protein engineering seeks to identify protein sequences with optimized properties. When guided by machine learning, protein sequence generation methods can draw on prior knowledge and experimental efforts to improve this process. In this review, we highlight recent applications of machine learning to generate protein sequences, focusing on the emerging field of deep generative methods.
蛋白质工程旨在寻找具有优化性质的蛋白质序列。当受到机器学习的指导时,蛋白质序列生成方法可以利用先前的知识和实验工作来改进这一过程。在这篇综述中,我们重点介绍了机器学习在生成蛋白质序列方面的最新应用,特别是在新兴的深度生成方法领域。