Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Neurochem Int. 2021 Sep;148:105083. doi: 10.1016/j.neuint.2021.105083. Epub 2021 May 27.
Chronic stress is a risk factor for the development of psychiatric illnesses through impairment of the ability to appropriately regulate physiological and behavioral responses, but the molecular events that lead to damage of hippocampal neurons remain unclear. The medicinal herb Spilanthes acmella Murr. has been used as a traditional medicine for various diseases and its extracts exhibit antioxidant activity. The present study explored the molecular signals of mitochondrial dynamics and investigated the beneficial effects of S. acmella Murr. An ethyl acetate extract of this plant was used to assess mitochondrial dynamics in response to chronic restraint stress (CRS) in male Sprague-Dawley rats. The results demonstrated that the S. acmella Murr. extract reduced the expression of mitochondrial fission protein but induced HSP60, MnSOD and ATPsynthase in the hippocampus of the CRS rats. In addition, S. acmella Murr. extract reversed depressive symptoms in the forced swim test. Our findings suggested that S. acmella Murr. extract provides a potential treatment of chronic stress, and that the mechanism is associated with the alleviation of neuronal injury and maintenance of mitochondrial function.
慢性应激通过损害适当调节生理和行为反应的能力，成为精神疾病发展的一个风险因素，但导致海马神经元损伤的分子事件仍不清楚。药用植物 Spilanthes acmella Murr. 已被用作治疗各种疾病的传统药物，其提取物具有抗氧化活性。本研究探讨了线粒体动力学的分子信号，并研究了 S. acmella Murr. 的有益作用。该植物的乙酸乙酯提取物用于评估雄性 Sprague-Dawley 大鼠慢性束缚应激（CRS）对线粒体动力学的影响。结果表明，S. acmella Murr. 提取物降低了线粒体分裂蛋白的表达，但诱导了 HSP60、MnSOD 和 ATPsynthase 在 CRS 大鼠的海马体中表达。此外，S. acmella Murr. 提取物在强迫游泳试验中逆转了抑郁症状。我们的研究结果表明，S. acmella Murr. 提取物提供了一种治疗慢性应激的潜在方法，其机制与减轻神经元损伤和维持线粒体功能有关。
