Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas 13200, Malaysia.
Int J Environ Res Public Health. 2021 Mar 29;18(7):3532. doi: 10.3390/ijerph18073532.
Oxidative stress and inflammation are two common risk factors of various life-threatening disease pathogenesis. In recent years, medicinal plants that possess antioxidant and anti-inflammatory activities were extensively studied for their potential role in treating and preventing diseases. (), which has been traditionally used to treat toothache in Malaysia, contains various active metabolites responsible for its anti-inflammatory, antiseptic, and anesthetic bioactivities. These bioactivities were attributed to bioactive compounds, such as phenolic, flavonoids, and alkamides. The review focused on the summarization of in vitro and in vivo experimental reports on the antioxidant and anti-inflammatory actions of , as well as how they contributed to potential health benefits in lowering the risk of diseases that were related to oxidative stress. The molecular mechanism of in reducing oxidative stress and inflammatory targets, such as inducible nitric oxide synthase (iNOS), transcription factors of the nuclear factor-κB family (NF-κB), cyclooxygenase-2 (COX-2), and mitogen-activated protein kinase (MAPK) signaling pathways were discussed. Besides, the antioxidant potential of was measured by total phenolic content (TPC), total flavonid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and superoxide anion radical scavenging (SOD) and thiobarbituric acid reactive substance (TBARS) assays. This review revealed that might have a potential role as a reservoir of bioactive agents contributing to the observed antioxidant, anti-inflammatory, and health beneficial effects.
氧化应激和炎症是各种危及生命的疾病发病机制的两个常见风险因素。近年来,具有抗氧化和抗炎活性的药用植物因其在治疗和预防疾病方面的潜在作用而受到广泛研究。(马来西亚传统上用于治疗牙痛的植物)含有各种负责其抗炎、防腐和麻醉生物活性的活性代谢物。这些生物活性归因于生物活性化合物,如酚类、类黄酮和酰胺。该综述重点总结了关于抗氧化和抗炎作用的体外和体内实验报告,以及它们如何有助于降低与氧化应激相关的疾病风险的潜在健康益处。还讨论了(马来西亚传统上用于治疗牙痛的植物)在降低氧化应激和炎症靶点(如诱导型一氧化氮合酶 (iNOS)、核因子-κB 家族转录因子 (NF-κB)、环氧化酶-2 (COX-2) 和丝裂原活化蛋白激酶 (MAPK) 信号通路)方面的分子机制。此外,还通过总酚含量 (TPC)、总黄酮含量 (TFC)、2,2-二苯基-1-苦基肼 (DPPH) 和超氧阴离子自由基清除 (SOD) 和硫代巴比妥酸反应物质 (TBARS) 测定来测量(马来西亚传统上用于治疗牙痛的植物)的抗氧化潜力。该综述表明,(马来西亚传统上用于治疗牙痛的植物)可能具有作为生物活性物质库的潜力,有助于观察到的抗氧化、抗炎和有益健康的作用。