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小花金纽扣的血管舒张和抗氧化活性

Vasorelaxant and antioxidant activities of Spilanthes acmella Murr.

作者信息

Wongsawatkul Orapin, Prachayasittikul Supaluk, Isarankura-Na-Ayudhya Chartchalerm, Satayavivad Jutamaad, Ruchirawat Somsak, Prachayasittikul Virapong

机构信息

Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand.

Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.

出版信息

Int J Mol Sci. 2008 Dec;9(12):2724-2744. doi: 10.3390/ijms9122724. Epub 2008 Dec 18.

DOI:10.3390/ijms9122724
PMID:19330100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2635640/
Abstract

This study reports the effect of Spilanthes acmella Murr. extracts on phenylephrine-induced contraction of rat thoracic aorta as well as their antioxidant activity. Results show that the extracts exert maximal vasorelaxations in a dose-dependent manner, but their effects are less than acetylcholine-induced nitric oxide (NO) vasorelaxation. Significant reduction of vasorelaxations is observed in both N(G)-nitro-l-arginine methyl ester (l-NAME) and indomethacin (INDO). In the presence of l-NAME plus INDO, synergistic effects are observed, leading to loss of vasorelaxation of both acetylcholine and the extracts. Similarly, the vasorelaxations of the extracts are completely abolished upon the removal of endothelial cells. This demonstrates that the extracts exhibit vasorelaxation via partially endothelium-induced NO and prostacyclin in a dose-dependent manner. Significantly, the ethyl acetate extract exerts immediate vasorelaxation (ED(50) 76.1 ng/mL) and is the most potent antioxidant (DPPH assay). The chloroform extract shows the highest vasorelaxation and antioxidation (SOD assay). These reveal a potential source of vasodilators and antioxidants.

摘要

本研究报告了金纽扣提取物对去氧肾上腺素诱导的大鼠胸主动脉收缩的影响及其抗氧化活性。结果表明，提取物以剂量依赖性方式发挥最大血管舒张作用，但其作用小于乙酰胆碱诱导的一氧化氮（NO）介导的血管舒张。在N（G）-硝基-L-精氨酸甲酯（L-NAME）和吲哚美辛（INDO）中均观察到血管舒张作用显著降低。在L-NAME加INDO存在的情况下，观察到协同作用，导致乙酰胆碱和提取物的血管舒张作用丧失。同样，去除内皮细胞后，提取物的血管舒张作用完全消失。这表明提取物通过部分内皮诱导的NO和前列环素以剂量依赖性方式表现出血管舒张作用。值得注意的是，乙酸乙酯提取物具有即时血管舒张作用（半数有效剂量（ED（50））为76.1 ng/mL），并且是最有效的抗氧化剂（二苯基苦味酰基自由基（DPPH）测定）。氯仿提取物显示出最高的血管舒张和抗氧化作用（超氧化物歧化酶（SOD）测定）。这些揭示了血管舒张剂和抗氧化剂的潜在来源。

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