Department of Medicine, Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA.
Department of Medicine, Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA.
Gastrointest Endosc Clin N Am. 2021 Jul;31(3):451-465. doi: 10.1016/j.giec.2021.03.003.
Helicobacter pylori is present in approximately one-half of the world's population. There are significant differences in prevalence based on region, age, race/ethnicity, and socioeconomic status. H pylori is the most common cause of infection-related cancers. Studies have demonstrated the relationship between H pylori infection and gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. H pylori has features and enzymatic properties allowing it to survive in the acidic stomach environment, and has specific virulence factors that promote an increased risk of gastric pathology. Eradication of H pylori is first-line therapy for mucosa-associated lymphoid tissue lymphoma and decreases the risk of gastric adenocarcinoma.
幽门螺杆菌存在于世界上大约一半的人口中。其流行率因地区、年龄、种族/民族和社会经济地位而有显著差异。幽门螺杆菌是感染相关癌症的最常见原因。研究表明，幽门螺杆菌感染与胃腺癌和黏膜相关淋巴组织淋巴瘤之间存在关联。幽门螺杆菌具有在酸性胃环境中生存的特征和酶学特性，并且具有特定的毒力因子，可增加胃病理的风险。根除幽门螺杆菌是黏膜相关淋巴组织淋巴瘤的一线治疗方法，可降低胃腺癌的风险。
