Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, 1030C MRB IV, 2215 Garland Avenue, Nashville, TN 37232-0252, USA; Veterans Affairs Tennessee Valley Health System, Nashville Campus, Nashville, TN, USA.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, 1030C MRB IV, 2215 Garland Avenue, Nashville, TN 37232-0252, USA.
Gastrointest Endosc Clin N Am. 2021 Jul;31(3):519-542. doi: 10.1016/j.giec.2021.03.006.
Gastric cancer is the fifth most common cause of cancer and the third leading cause of cancer-related deaths globally. The number of gastric cancer-related deaths is only projected to increase, attributable primarily to the expanding aging population. Prevention is a mainstay of gastric cancer control programs, particularly in the absence of accurate, noninvasive modalities for screening and early detection, and the absence of an infrastructure for this purpose in the majority of countries worldwide. Herein, we discuss the evidence for several chemopreventive agents, along with putative mechanisms. There remains a clear, unmet need for primary chemoprevention trials for gastric cancer.
胃癌是全球第五大常见癌症，也是癌症相关死亡的第三大主要原因。预计胃癌相关死亡人数还会增加，这主要归因于不断扩大的老年人口。预防是胃癌控制计划的主要内容，特别是在缺乏准确、非侵入性的筛查和早期检测手段，以及在全球大多数国家都没有为此目的建立基础设施的情况下。本文讨论了几种化学预防剂的证据，以及推测的机制。胃癌的一级化学预防试验仍然存在明显的、未满足的需求。
