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常染色体显性遗传多囊肾病患者伴肾细胞癌相关副肿瘤性多发性肌炎。

Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease.

机构信息

Department of Neurology, Toranomon Hospital, Japan.

Department of Nephrology, Toranomon Hospital, Japan.

出版信息

Intern Med. 2021 Nov 15;60(22):3577-3580. doi: 10.2169/internalmedicine.7417-21. Epub 2021 May 29.

DOI:10.2169/internalmedicine.7417-21
PMID:34053989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8666206/
Abstract

We herein report a 70-year-old man with malaise and muscle weakness that had developed within a month. The patient also had abdominal fullness due to polycystic kidney disease. Severe proximal skeletal muscle weakness and mild elevation of creatinine kinase to 301 IU/L were noted. A muscle biopsy of the right bicep showed polymyositis. Computed tomography showed a right renal mass, and an analysis after right nephrectomy identified clear cell carcinoma. The muscle weakness subsided one month after nephrectomy and intravenous immunoglobulin therapy. Therefore, we suspect that the development of polymyositis in this patient was closely related to renal cell carcinoma.

摘要

我们在此报告一例 70 岁男性，出现不适和肌肉无力，症状在一个月内发展。患者还患有多囊肾病导致的腹部饱满。检查发现严重的近端骨骼肌无力和轻度肌酸激酶升高至 301IU/L。右肱二头肌的肌肉活检显示为多发性肌炎。计算机断层扫描显示右肾肿块，右肾切除后的分析确定为肾透明细胞癌。肾切除和静脉注射免疫球蛋白治疗一个月后，肌肉无力缓解。因此，我们怀疑该患者多发性肌炎的发展与肾细胞癌密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f21/8666206/6b30e7d1a062/1349-7235-60-3577-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f21/8666206/4da8376d66a8/1349-7235-60-3577-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f21/8666206/bc572bed1e2f/1349-7235-60-3577-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f21/8666206/322ede50df2c/1349-7235-60-3577-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f21/8666206/6b30e7d1a062/1349-7235-60-3577-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f21/8666206/4da8376d66a8/1349-7235-60-3577-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f21/8666206/bc572bed1e2f/1349-7235-60-3577-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f21/8666206/322ede50df2c/1349-7235-60-3577-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f21/8666206/6b30e7d1a062/1349-7235-60-3577-g004.jpg

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2
Necrotizing myopathy as a paraneoplastic syndrome associated with renal cell carcinoma.坏死性肌病作为一种与肾细胞癌相关的副肿瘤综合征。
Acta Clin Belg. 2015 Feb;70(1):61-4. doi: 10.1179/2295333714Y.0000000080. Epub 2014 Sep 30.
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Renal cell carcinoma-associated adult dermatomyositis treated laparoscopic nephrectomy.
维持性血液透析患者因副肿瘤综合征导致的肾细胞癌相关性糖尿病：一例报告
Kidney Med. 2022 Apr 29;4(6):100477. doi: 10.1016/j.xkme.2022.100477. eCollection 2022 Jun.
肾细胞癌相关的成人皮肌炎行腹腔镜肾切除术治疗。
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Arthritis Rheum. 2012 Feb;64(2):523-32. doi: 10.1002/art.33379.
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