Yoshimura Yusuke, Suwabe Tatsuya, Miki Katsuyuki, Yokoyama Takayoshi, Kono Kei, Kinowaki Keiichi, Kato Ikuma, Nagashima Yoji, Nishikori Asami, Sato Yasuharu, Kurihara Shigekazu, Oba Yuki, Mizuno Hiroki, Sekine Akinari, Yamanouchi Masayuki, Kamiyama Manabu, Ishii Yasuo, Nakamura Yuki, Ubara Yoshifumi, Sawa Naoki
Nephrology Center, Toranomon Hospital Kajigaya, Kawasaki, Kanagawa 213-8587, Japan.
Department of Pathology, Toranomon Hospital, Tokyo 105-8470, Japan.
Oncol Lett. 2024 Jul 22;28(4):448. doi: 10.3892/ol.2024.14581. eCollection 2024 Oct.
A man with polycystic kidney disease and a history of renal transplantation at the age of 55 years developed seronegative rheumatoid arthritis (RA) at the age of 68 years. Treatment with a biological derivative led to remission; however, the patient relapsed 2 years later. After being switched to baricitinib, the patient again achieved remission. After 2 years, when the patient was aged 72 years, RA recurred, and the right native kidney became enlarged due to the presence of a large tumor. Surgical nephrectomy was performed, and the tumor was classified as renal cell carcinoma (RCC), not otherwise specified. The cancer tissue comprised sarcomatoid and rhabdoid cells with marked neutrophil infiltration, and the tumor cells were positive for interleukin-6. The patient, aged 73 years, experienced a resolution of joint pain following surgical intervention; however, they died because of systemic metastases ~10 weeks post-operation. Based on the clinical course, the RA-like lesions and subsequent RCC were considered to represent a paraneoplastic syndrome.
一名患有多囊肾病且在55岁时接受过肾移植的男性，在68岁时患上了血清阴性类风湿关节炎（RA）。使用生物衍生物治疗后病情缓解；然而，患者在2年后复发。改用巴瑞替尼后，患者再次实现缓解。2年后，患者72岁时，RA复发，由于存在一个大肿瘤，右侧原生肾增大。进行了手术肾切除术，肿瘤被分类为肾细胞癌（RCC），未另作说明。癌组织由肉瘤样和横纹肌样细胞组成，伴有明显的中性粒细胞浸润，肿瘤细胞白细胞介素-6呈阳性。该患者73岁，手术干预后关节疼痛缓解；然而，他们在术后约10周因全身转移而死亡。根据临床病程，类风湿关节炎样病变及随后的肾细胞癌被认为代表一种副肿瘤综合征。
