Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pharmacognosy Department, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
Front Immunol. 2021 May 12;12:659038. doi: 10.3389/fimmu.2021.659038. eCollection 2021.
Protein inhibitors of activated STAT (PIAS) are involved in the regulation of the JAK/STAT signaling pathway and have interactions with NF-κB, p73 and p53. These proteins regulate immune responses; therefore dysregulation in their expression leads to several immune-mediated disorders. In the present study, we examined expression of - in peripheral blood of patients with acute/chronic inflammatory demyelinating polyradiculoneuropathy (AIDP/CIDP) compared with healthy subjects. We demonstrated down-regulation of all genes in both AIDP and CIDP cases compared with controls. Similarly, comparisons in gender-based groups revealed down-regulation of these gene0s in patients of each gender compared with gender-matched controls. There was no significant difference in expression of genes between AIDP and CIDP cases. Based on the area under the receiver operating characteristic curves, - genes could distinguish between inflammatory demyelinating polyradiculoneuropathy and healthy status with accuracy values of 0.87, 0.87, 0.79 and 0.80, respectively. In differentiation between AIDP cases and healthy controls, these values were 0.92, 0.92, 0.83 and 0.86, respectively. Finally, - genes could discriminate CIDP from healthy status with accuracy values of 0.82, 0.83, 0.75 and 0.75, respectively. The current study underscores the role of genes in the pathogenesis of inflammatory demyelinating polyradiculoneuropathy and their potential usage as biomarkers.
激活 STAT 的蛋白抑制剂（PIAS）参与 JAK/STAT 信号通路的调节，与 NF-κB、p73 和 p53 相互作用。这些蛋白质调节免疫反应；因此，它们的表达失调会导致几种免疫介导的疾病。在本研究中，我们检测了急性/慢性炎症性脱髓鞘性多发性神经病（AIDP/CIDP）患者外周血中-的表达，与健康受试者进行了比较。我们发现在 AIDP 和 CIDP 病例中与对照组相比，所有基因的表达均下调。同样，在基于性别的组比较中，与性别匹配的对照组相比，每个性别患者的这些基因均下调。AIDP 和 CIDP 病例之间的基因表达没有显著差异。基于接受者操作特征曲线下的面积，-基因可以区分炎症性脱髓鞘性多发性神经病和健康状态，准确性值分别为 0.87、0.87、0.79 和 0.80。在 AIDP 病例与健康对照组之间的区分中，这些值分别为 0.92、0.92、0.83 和 0.86。最后，-基因可以区分 CIDP 与健康状态，准确性值分别为 0.82、0.83、0.75 和 0.75。本研究强调了基因在炎症性脱髓鞘性多发性神经病发病机制中的作用及其作为生物标志物的潜在用途。
