Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Front Immunol. 2021 Jul 19;12:712859. doi: 10.3389/fimmu.2021.712859. eCollection 2021.
Acquired immune-mediated polyneuropathies are classified to some subtypes among them are acute and chronic inflammatory demyelinating polyradiculoneuropathies (AIDP and CIDP). These two conditions share some common signs and underlying mechanisms. Based on the roles of () genes in the modulation of immune system reactions, these genes might be involved in the pathogenesis of these conditions. We evaluated expression of and genes in the leukocytes of 32 cases of CIDP, 19 cases of AIDP and 40 age- and sex-matched controls using real time PCR method. The Bayesian regression model was used to estimate differences in mean values of genes expressions between cases and control group. Expression levels of and were significantly lower in male patients compared with controls. This sex-specific pattern was also observed for down-regulation. Based on the area under curve values in Receiver Operating Characteristics (ROC) curve, diagnostic powers of , , and genes in the mentioned disorder were 0.61, 0.73, 0.68 and 0.58, respectively. Expression of none of genes was correlated with age of enrolled cases. The current study shows evidences for participation of genes in the pathophysiology of acquired immune-mediated polyneuropathies.
获得性免疫介导的多发性神经病分为一些亚型，其中包括急性和慢性炎症性脱髓鞘性多发性神经病（AIDP 和 CIDP）。这两种情况有一些共同的体征和潜在机制。基于 （）基因在免疫系统反应调节中的作用，这些基因可能参与这些疾病的发病机制。我们使用实时 PCR 方法评估了 32 例 CIDP、19 例 AIDP 和 40 名年龄和性别匹配的对照组患者白细胞中 和 基因的表达。贝叶斯回归模型用于估计病例组和对照组之间基因表达均值的差异。与对照组相比，男性患者的 和 表达水平明显降低。这种性别特异性下调模式也观察到 。根据受试者工作特征 (ROC) 曲线下的面积值， 、 、 和 基因在所述疾病中的诊断效能分别为 0.61、0.73、0.68 和 0.58。纳入病例的年龄与任何基因的表达均无相关性。本研究为 基因参与获得性免疫介导的多发性神经病的病理生理学提供了证据。
