Dharmasaroja Pornpatr A, Assanasen Jintana, Pongpakdee Sunsanee, Jaisin Kankamol, Lolekha Praween, Phanasathit Muthita, Cheewakriengkrai Laksanun, Chotipanich Chanisa, Witoonpanich Pirada, Pitiyarn Sutisa, Lertwilaiwittaya Pongtawat, Dejthevaporn Charungthai, Limwongse Chanin, Phanthumchinda Kammant
Department of Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Faculty of Medicine, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand.
Dement Geriatr Cogn Dis Extra. 2021 Apr 15;11(1):64-70. doi: 10.1159/000515676. eCollection 2021 Jan-Apr.
Molecular imaging has been developed and validated in Thai patients, comprising a portion of patients in the dementia registry. This should provide a more accurate diagnosis of the etiology of dementia, which was the focus of this study.
This was a multicenter dementia study. The baseline characteristics, main presenting symptoms, and results of investigations and cognitive tests of the patients were electronically collected in the registry. Functional imaging and/or molecular imaging were performed in patients with an equivocal diagnosis of the causes of dementia, especially in atypical dementia or young onset dementia (YOD).
There were 454 patients in the study. The mean age of the patients was 78 years, with 60% female. Functional imaging and/or molecular imaging were performed in 57 patients (57/454 patients, 13%). The most common cause of dementia was Alzheimer's disease (AD; 50%), followed by vascular dementia (VAD; 24%), dementia with Lewy bodies (6%), Parkinson's disease dementia (6%), frontotemporal dementia (FTD; 2.6%), progressive supranuclear palsy (2%), multiple system atrophy (0.8%), and corticobasal syndrome (0.4%). YOD accounted for 17% (77/454 patients), with a mean age of 58 years. The causes of YOD were early onset amnestic AD (44%), VAD (16%), behavioral variant FTD (8%), posterior cortical atrophy (6.5%), and logopenic variant primary progressive aphasia (5.2%).
AD was the most common cause of dementia in Thai patients and the distribution of other types of dementia and main presenting symptoms were similar to previous reports in Western patients; however, the proportion of YOD was higher.
分子成像技术已在泰国患者中得到发展和验证，这些患者是痴呆症登记系统中的一部分。这应该能为痴呆症病因提供更准确的诊断，而这正是本研究的重点。
这是一项多中心痴呆症研究。患者的基线特征、主要症状表现以及检查和认知测试结果通过电子方式收集到登记系统中。对痴呆症病因诊断不明确的患者，尤其是非典型痴呆或早发性痴呆（YOD）患者，进行功能成像和/或分子成像检查。
该研究共有454名患者。患者的平均年龄为78岁，女性占60%。57名患者（57/454名患者，占13%）接受了功能成像和/或分子成像检查。痴呆症最常见的病因是阿尔茨海默病（AD；50%），其次是血管性痴呆（VAD；24%）、路易体痴呆（6%）、帕金森病痴呆（6%）、额颞叶痴呆（FTD；2.6%）、进行性核上性麻痹（2%）、多系统萎缩（0.8%）和皮质基底节综合征（0.4%）。早发性痴呆占17%（77/454名患者），平均年龄为58岁。早发性痴呆的病因包括早发性遗忘型AD（44%）、VAD（16%）、行为变异型FTD（8%）、后部皮质萎缩（6.5%）和语法缺失型原发性进行性失语（5.2%）。
AD是泰国患者痴呆症最常见的病因，其他类型痴呆症的分布及主要症状表现与先前西方患者的报道相似；然而，早发性痴呆的比例更高。
