Ren Jia-Xin, Sun Xin, Yan Xiu-Li, Guo Zhen-Ni, Yang Yi
Department of Neurology, The First Hospital of Jilin University, Changchun, China.
School of Clinical Medicine, Jilin University, Changchun, China.
Front Cell Neurosci. 2020 Jul 13;14:218. doi: 10.3389/fncel.2020.00218. eCollection 2020.
Ferroptosis is mechanism for non-apoptotic, iron-dependent, oxidative cell death that is characterized by glutathione consumption and lipid peroxides accumulation. Ferroptosis is crucially involved in neurological diseases, including neurodegeneration, stroke and neurotrauma. This review provides detailed discussions of the ferroptosis mechanisms in these neurological diseases. Moreover, it summarizes recent drugs that target ferroptosis for neurological disease treatment. Furthermore, it compares the differences and relationships among the various cell death mechanisms involved in neurological diseases. Elucidating the ferroptosis role in the brain can improve the understanding of neurological disease mechanism and provide potential prevention and treatment interventions for acute and chronic neurological diseases.
铁死亡是一种非凋亡性、铁依赖性的氧化性细胞死亡机制，其特征是谷胱甘肽消耗和脂质过氧化物积累。铁死亡在包括神经退行性变、中风和神经创伤在内的神经系统疾病中起着至关重要的作用。本文综述详细讨论了这些神经系统疾病中的铁死亡机制。此外，总结了最近针对铁死亡用于治疗神经系统疾病的药物。此外，还比较了神经系统疾病中各种细胞死亡机制之间的差异和关系。阐明铁死亡在大脑中的作用可以增进对神经系统疾病机制的理解，并为急性和慢性神经系统疾病提供潜在的预防和治疗干预措施。
