Pellicelli Adriano, Giannelli Valerio, Zoli Valerio, Regine Giovanni, Cortese Andrea, Ettorre Giuseppe M, Carmenini Enrico, Pellicelli Valeria, Rigacci Luigi
Liver Unit, Department of Liver Transplant, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy.
Hematology Unit, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy.
Oxf Med Case Reports. 2021 May 24;2021(5):omab022. doi: 10.1093/omcr/omab022. eCollection 2021 May.
The favorable impact of antiviral therapy on low-grade hepatitis C virus (HCV)-related non-Hodgkin lymphoma manifesting as marginal zone lymphoma (MZL) has been reported in some clinical studies. However, primary HCV-related marginal zone lymphomas (MZLs) confined to the liver have not been described in the literature nor have the resolution of liver lymphoma through anti-HCV eradication treatment. The authors report a genotype 1b HCV-positive patient with chronic hepatitis who exhibited lesions involving both hepatic lobes resembling hepatocellular carcinoma. Liver biopsy revealed an MZL of the liver. Antiviral treatment using sofosbuvir associated with simeprevir as unique treatment was started and resulted in complete haematological response. In HCV-related MZL isolated to the liver, antiviral treatment has led to the eradication of viral infection and a complete haematological response. Antiviral therapy should be considered as a first-line treatment for HCV-related primary MZLs of the liver.
一些临床研究报道了抗病毒治疗对表现为边缘区淋巴瘤（MZL）的低度丙型肝炎病毒（HCV）相关非霍奇金淋巴瘤的有利影响。然而，文献中尚未描述局限于肝脏的原发性HCV相关边缘区淋巴瘤（MZL），也未提及通过抗HCV根除治疗使肝脏淋巴瘤消退的情况。作者报告了一名基因型1b HCV阳性的慢性肝炎患者，其肝脏两叶均出现类似肝细胞癌的病变。肝活检显示为肝脏MZL。开始使用索磷布韦联合西米普明进行抗病毒治疗作为唯一治疗方法，结果实现了完全血液学缓解。在孤立于肝脏的HCV相关MZL中，抗病毒治疗导致病毒感染根除和完全血液学缓解。抗病毒治疗应被视为HCV相关肝脏原发性MZL的一线治疗方法。
