Villaume Matthew T, Patel Dilan, Lopez Christine, Patel Vivek, Diggs Pauleatha, Harmsen Hannah, Thompson Mary Ann, Morgan David
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Hematology and Bone Marrow Transplant, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
World J Oncol. 2020 Jun;11(3):122-125. doi: 10.14740/wjon1285. Epub 2020 May 14.
Primary dural marginal zone lymphomas (MZLs) are exceptionally rare, with fewer than 100 cases reported to date. While the association between hepatitis C virus (HCV) infection and lymphoma is well established, it is unclear if this association extends to all anatomic sites. Here we report a case of dural MZL in a 61-year-old woman with an HCV infection. To our knowledge, this is the first report of a dural MZL associated with an HCV infection in an immunocompetent patient and was successfully treated with radiotherapy and rituximab. As such, future cases of primary MZL found in the dura should prompt consideration of co-infection with microbials such as HCV and upfront treatment with anti-virals should be considered.
原发性硬脑膜边缘区淋巴瘤（MZL）极为罕见，迄今为止报道的病例不足100例。虽然丙型肝炎病毒（HCV）感染与淋巴瘤之间的关联已得到充分证实，但尚不清楚这种关联是否适用于所有解剖部位。本文报告了一例61岁感染HCV的女性硬脑膜MZL病例。据我们所知，这是首例免疫功能正常的患者中与HCV感染相关的硬脑膜MZL报告，该病例通过放疗和利妥昔单抗成功治愈。因此，未来在硬脑膜中发现的原发性MZL病例应促使人们考虑是否合并HCV等微生物感染，并应考虑采用抗病毒药物进行前期治疗。
