Kim Dong Hyun, Yang Hee Kyung, Han Sang Beom, Hwang Jeong-Min
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Department of Ophthalmology, Kangwon National University College of Medicine, Kangwon National University Hospital, Chuncheon, Kangwon, Republic of Korea.
J Ophthalmol. 2021 May 4;2021:5574194. doi: 10.1155/2021/5574194. eCollection 2021.
To investigate the effects of topical brimonidine 0.15% instillation on conjunctival injection after strabismus surgery in children.
We retrospectively analyzed 63 Korean children who underwent strabismus surgery for intermittent exotropia. Patients received topical brimonidine 0.15% after surgery for up to 4 weeks. Conjunctival injection was objectively assessed using a software that automatically scored the region of interest from the image of the bulbar conjunctiva. Conjunctival injection scores were compared with those of the control group who were not prescribed topical brimonidine.
The mean scores of conjunctival injection after rectus muscle recession and resection were significantly lower in the brimonidine group than the controls at 4 weeks after surgery ( = 0.008 and 0.046, respectively). There was no significant difference in intraocular pressure between the two groups. No adverse effects, such as dry mouth, fatigue/drowsiness, headache, sedation, hypotension, or bradycardia, were reported.
Administration of topical brimonidine 0.15% after strabismus surgery is efficacious and safe in reducing postoperative conjunctival injection.
探讨0.15%溴莫尼定滴眼液局部滴注对儿童斜视手术后结膜充血的影响。
我们回顾性分析了63例因间歇性外斜视接受斜视手术的韩国儿童。患者术后接受0.15%溴莫尼定滴眼液局部滴注，持续4周。使用一款软件对球结膜图像中的感兴趣区域进行自动评分，从而客观评估结膜充血情况。将结膜充血评分与未使用局部溴莫尼定的对照组进行比较。
术后4周，溴莫尼定组直肌后徙和切除术结膜充血的平均评分显著低于对照组（分别为 = 0.008和0.046）。两组眼压无显著差异。未报告口干、疲劳/嗜睡、头痛、镇静、低血压或心动过缓等不良反应。
斜视手术后局部滴注0.15%溴莫尼定在减轻术后结膜充血方面有效且安全。
