Fan Junjie, Liang Hua, Zhang Xing, Chen Xingfa, Duan Xiaoyi, Li Lei, He Dalin, Wu Kaijie
Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Urology, Baoji Central Hospital, Baoji, China.
Front Oncol. 2021 May 13;11:683343. doi: 10.3389/fonc.2021.683343. eCollection 2021.
Metastases from prostate cancer (PCa) to the penis are extremely rare, and few case reports exist in the literature. Because most patients usually present with multiple distant metastases at diagnosis, the prognosis is very poor. With the wide application of prostate-specific membrane antigen (PSMA) PET/CT, penile metastases may be detected at an early stage. Thus, questions regarding whether early diagnosis and precise treatment will equate to a survival advantage have recently been raised. In the present study, we reported 3 cases of penile metastasis from castration-resistant PCa. Moreover, a patient with asymptomatic penile metastases was diagnosed by F-PSMA PET/CT followed by lesion biopsy, and the prognosis was very well, despite with an aggressive pathological feature and low treatment intensity. In addition, we performed a literature review and found 62.5% of asymptomatic penile metastases were diagnosed by PSMA PET/CT in past seven years. Thus, we believe that PSMA PET/CT may detect more asymptomatic penile metastases in future, which led to early diagnosis, treatment and survival advantage.
前列腺癌（PCa）转移至阴茎极为罕见，文献中仅有少数病例报告。由于大多数患者在诊断时通常已出现多处远处转移，预后很差。随着前列腺特异性膜抗原（PSMA）PET/CT的广泛应用，阴茎转移可能在早期被检测到。因此，最近有人提出关于早期诊断和精确治疗是否等同于生存优势的问题。在本研究中，我们报告了3例去势抵抗性PCa阴茎转移病例。此外，1例无症状阴茎转移患者经F-PSMA PET/CT诊断后进行病变活检，尽管病理特征侵袭性强且治疗强度低，但预后良好。另外，我们进行了文献综述，发现过去七年中62.5%的无症状阴茎转移是通过PSMA PET/CT诊断的。因此，我们认为PSMA PET/CT未来可能检测到更多无症状阴茎转移，从而实现早期诊断、治疗并带来生存优势。
