Lv Gang, Yuan Jing, Xiong Xiaomo, Li Minghui
Department of General Surgery, Chinese PLA General Hospital, Beijing, China.
Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, China.
Front Med (Lausanne). 2021 May 14;8:670370. doi: 10.3389/fmed.2021.670370. eCollection 2021.
The emergency use authorization for coronavirus disease 2019 (COVID-19) vaccines brought both hopes and concerns to the Americans and others. We aimed to estimate the mortality rate of COVID-19 vaccination and presented characteristics of deaths following COVID-19 vaccination. Data on deaths following COVID-19 vaccination were obtained from the Vaccine Adverse Event Reporting System (VAERS) from December 11, 2020 through January 8, 2021. The Centers for Disease Control and Prevention (CDC) COVID Data Tracker was used to identify the total number of people receiving COVID-19 vaccines during the same period to estimate the mortality rate. Stratified analysis was conducted by the location of vaccination. As of January 8, 2021, 55 deaths were reported, and the mortality rate of COVID-19 vaccination was 8.2 per million population. A total of 37 deaths were reported among long-term care facility residents, and the mortality rate was 53.4 per million population. Top reported comorbidities associated with deaths included hypertension, dementia, chronic obstructive pulmonary disease (COPD), diabetes, and heart failure. In addition, dementia was more likely to be associated with deaths vaccinated at long-term care facilities than at other locations. The benefits of COVID-19 vaccines outweigh the potential risks in older frail populations, and our findings do not support actions to exclude older adults from being vaccinated. However, continued monitoring of COVID-19 vaccination is still warranted.
2019冠状病毒病（COVID-19）疫苗的紧急使用授权给美国人和其他人带来了希望和担忧。我们旨在估计COVID-19疫苗接种的死亡率，并呈现COVID-19疫苗接种后死亡的特征。2020年12月11日至2021年1月8日期间，COVID-19疫苗接种后死亡的数据来自疫苗不良事件报告系统（VAERS）。疾病控制和预防中心（CDC）的COVID数据追踪器用于确定同一时期接受COVID-19疫苗接种的总人数，以估计死亡率。按接种地点进行分层分析。截至2021年1月8日，报告了55例死亡，COVID-19疫苗接种的死亡率为每百万人口8.2例。长期护理机构居民中报告了37例死亡，死亡率为每百万人口53.4例。报告的与死亡相关的最常见合并症包括高血压、痴呆、慢性阻塞性肺疾病（COPD）、糖尿病和心力衰竭。此外，与其他地点相比，痴呆在长期护理机构接种疫苗后死亡中更可能相关。在体弱的老年人群中，COVID-19疫苗的益处大于潜在风险，我们的研究结果不支持将老年人排除在接种疫苗之外的行动。然而，仍有必要继续监测COVID-19疫苗接种情况。
