Department of Psychological Sciences, University of Connecticut, Storrs, CT 06269, USA.
Department of Physics, University of Connecticut, Storrs, CT 06269, USA.
Biomed Res Int. 2021 May 18;2021:6645688. doi: 10.1155/2021/6645688. eCollection 2021.
As of December 2020, since the beginning of the year 2020, the COVID-19 pandemic has claimed worldwide more than 1 million lives and has changed human life in unprecedented ways. Despite the fact that the pandemic is far from over, several countries managed at least temporarily to make their first-wave COVID-19 epidemics to subside to relatively low levels. Combining an epidemiological compartment model and a stability analysis as used in nonlinear physics and synergetics, it is shown how the first-wave epidemics in the state of New York and nationwide in the USA developed through three stages during the first half of the year 2020. These three stages are the outbreak stage, the linear stage, and the subsiding stage. Evidence is given that the COVID-19 outbreaks in these two regions were due to instabilities of the COVID-19 free states of the corresponding infection dynamical systems. It is shown that from stage 1 to stage 3, these instabilities were removed, presumably due to intervention measures, in the sense that the COVID-19 free states were stabilized in the months of May and June in both regions. In this context, stability parameters and key directions are identified that characterize the infection dynamics in the outbreak and subsiding stages. Importantly, it is shown that the directions in combination with the sign-switching of the stability parameters can explain the observed rise and decay of the epidemics in the state of New York and the USA. The nonlinear physics perspective provides a framework to obtain insights into the nature of the COVID-19 dynamics during outbreak and subsiding stages and allows to discuss possible impacts of intervention measures. For example, the directions can be used to determine how different populations (e.g., exposed versus symptomatic individuals) vary in size relative to each other during the course of an epidemic. Moreover, the timeline of the computationally obtained stages can be compared with the history of the implementation of intervention measures to discuss the effectivity of such measures.
截至 2020 年 12 月,自 2020 年年初以来,COVID-19 大流行已在全球范围内导致超过 100 万人死亡,并以前所未有的方式改变了人类的生活。尽管大流行远未结束,但一些国家至少暂时成功地将其第一波 COVID-19 疫情降至相对较低水平。本文结合流行病学 compartment 模型和非线性物理和协同作用中的稳定性分析,展示了 2020 年上半年纽约州和美国全国范围内第一波疫情如何通过三个阶段发展。这三个阶段是爆发阶段、线性阶段和消退阶段。有证据表明,这两个地区的 COVID-19 爆发是由于相应感染动力学系统的 COVID-19 自由状态的不稳定性。结果表明,从第 1 阶段到第 3 阶段,这些不稳定性被消除了,这可能是由于干预措施,因为在这两个地区,COVID-19 自由状态在 5 月和 6 月得到了稳定。在这种情况下,确定了稳定参数和关键方向,这些参数和方向可以描述爆发和消退阶段的感染动力学。重要的是,结果表明,方向结合稳定性参数的符号切换可以解释纽约州和美国 COVID-19 疫情的上升和下降。非线性物理视角提供了一个框架,以深入了解爆发和消退阶段 COVID-19 动力学的本质,并允许讨论干预措施的可能影响。例如,方向可用于确定在疫情过程中,不同人群(例如,暴露人群与症状人群)如何相对于彼此变化。此外,计算得出的阶段的时间线可以与干预措施实施的历史进行比较,以讨论这些措施的有效性。