Khanna R, Nain C K, Mehta S, Vinayak V K
Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Pediatr Infect Dis J. 1988 Jul;7(7):492-8. doi: 10.1097/00006454-198807000-00009.
The specific anti-plasma membrane- or surface-specific serum antibodies to Mr 82,000 antigen of Giardia lamblia trophozoites in cases of persistent and nonpersistent giardiasis in a pediatric population indicated significantly low concentrations of these antibodies in patients with persistent giardiasis. There was an insignificant difference in the amount of antibodies to whole trophozoite extract in persistent and nonpersistent giardiasis or asymptomatic carriers. The acute/nonpersistent cases had predominantly IgM class antigiardial antibodies, whereas persistent and asymptomatic carriers had antigiardial antibodies of the IgG class. The inability of persistent cases of giardiasis to clear infection appears to be related to low concentrations of antiplasma membrane/anti-Mr 82,000 antigiardial antibodies.
在儿科持续性和非持续性贾第虫病病例中，针对蓝氏贾第鞭毛虫滋养体82,000道尔顿抗原的特异性抗质膜或表面特异性血清抗体表明，持续性贾第虫病患者体内这些抗体的浓度显著降低。在持续性和非持续性贾第虫病或无症状携带者中，针对整个滋养体提取物的抗体量没有显著差异。急性/非持续性病例主要有IgM类抗贾第虫抗体，而持续性和无症状携带者有IgG类抗贾第虫抗体。持续性贾第虫病病例无法清除感染似乎与抗质膜/抗82,000道尔顿抗贾第虫抗体浓度低有关。
