组织蛋白酶 B 的遗传多态性与中国人群胃癌风险和预后相关。
Genetic polymorphisms of Cathepsin B are associated with gastric cancer risk and prognosis in a Chinese population.
机构信息
Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
出版信息
Cancer Biomark. 2021;32(2):189-198. doi: 10.3233/CBM-203208.
BACKGROUND
Genetic polymorphisms are believed to represent a key aspect of predisposition to gastric cancer (GC). Therefore, considering the important role of Cathepsin B (CTSB) in promoting cancer onset and development, it could be very worthful to explore the function of CTSB-related genetic polymorphisms in GC.
OBJECTIVE
In this study, we investigated the correlation of CTSB-related polymorphisms (rs9009A>T, rs6731T>C, rs1293303G>C, rs1874547C>T, rs3779659C>T, rs17814426C>T and rs148669985C>T) with GC risk and prognosis in a case-control study of 994 cases and 1000 controls.
METHODS
All tag single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-ligase detection reaction (PCR-LDR) sequencing technology.
RESULTS
The results indicated rs9009, rs6731 and rs17814426 correlated with decreased risks of GC (HR = 0.97, p< 0.001; HR = 0.86, P= 0.019; HR = 0.85, P= 0.017; respectively). Stratification analysis further showed rs17814426 variant genotypes correlated with earlier T stage (p= 0.044). In addition, GC patients carrying the C allele of rs6371 had better overall prognosis (HR = 0.62, 95%CI = 0.44-0.88).
CONCLUSION
Our results firstly suggested the importance of CTSB-related polymorphisms on GC which could predict GC risk and prognosis.
背景
遗传多态性被认为是胃癌（GC）易感性的一个关键方面。因此，考虑到组织蛋白酶 B（CTSB）在促进癌症发生和发展中的重要作用，探索 CTSB 相关遗传多态性与 GC 的关系非常有价值。
目的
本研究通过病例对照研究，对 994 例病例和 1000 例对照进行研究，探讨 CTSB 相关多态性（rs9009A>T、rs6731T>C、rs1293303G>C、rs1874547C>T、rs3779659C>T、rs17814426C>T 和 rs148669985C>T）与 GC 风险和预后的相关性。
方法
采用聚合酶链反应-连接酶检测反应（PCR-LDR）测序技术对所有标签单核苷酸多态性（SNP）进行基因分型。
结果
结果表明，rs9009、rs6731 和 rs17814426 与 GC 风险降低相关（HR=0.97，p<0.001；HR=0.86，P=0.019；HR=0.85，P=0.017；分别）。分层分析进一步表明，rs17814426 变异基因型与较早的 T 分期相关（p=0.044）。此外，携带 rs6371 C 等位基因的 GC 患者总体预后较好（HR=0.62，95%CI=0.44-0.88）。
结论
本研究首次表明 CTSB 相关多态性对 GC 的重要性，可能预测 GC 的风险和预后。
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