放线菌菌株改良的合成生物学方法。
Synthetic biology approaches to actinomycete strain improvement.
机构信息
Department of Chemistry, Manchester Institute of Biotechnology, Manchester Synthetic Biology Research Centre SYNBIOCHEM, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.
出版信息
FEMS Microbiol Lett. 2021 Jun 11;368(10). doi: 10.1093/femsle/fnab060.
Abstract
Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.
摘要
它们的生化多样性和生物技术重要性使得放线菌成为使用合成生物学工具包进行雄心勃勃的基因工程的有吸引力的目标。但是，它们复杂的生物学也带来了独特的挑战。这篇迷你综述从放线菌的角度讨论了合成生物学方法的一些最新进展，并介绍了它们在理性改进工业相关菌株中的应用实例。
相似文献
1
Synthetic biology approaches to actinomycete strain improvement.放线菌菌株改良的合成生物学方法。
FEMS Microbiol Lett. 2021 Jun 11;368(10). doi: 10.1093/femsle/fnab060.
2
Synthetic biology advances and applications in the biotechnology industry: a perspective.合成生物学在生物技术产业中的进展与应用：一个视角。
J Ind Microbiol Biotechnol. 2018 Jul;45(7):449-461. doi: 10.1007/s10295-018-2056-y. Epub 2018 Jun 18.
3
Editorial: Yeast synthetic biology: new tools to unlock cellular function.社论：酵母合成生物学：解锁细胞功能的新工具
FEMS Yeast Res. 2015 Feb;15(1):1. doi: 10.1093/femsyr/fou003. Epub 2015 Jan 16.
4
Synthetic Biology Expands the Industrial Potential of Yarrowia lipolytica.合成生物学拓展了解脂耶氏酵母的工业潜力。
Trends Biotechnol. 2018 Oct;36(10):1085-1095. doi: 10.1016/j.tibtech.2018.05.004. Epub 2018 Jun 4.
5
[The strategies and research progresses of rational improvement of the yield of microbial drug- A review].[微生物药物产量合理提高的策略与研究进展——综述]
Wei Sheng Wu Xue Bao. 2016 Mar 4;56(3):454-60.
6
Synthetic Biology for Specialty Chemicals.用于特种化学品的合成生物学
Annu Rev Chem Biomol Eng. 2015;6:35-52. doi: 10.1146/annurev-chembioeng-061114-123303. Epub 2015 Jan 30.
7
[Application of systems biology and synthetic biology in strain improvement for biofuel production].系统生物学与合成生物学在生物燃料生产菌株改良中的应用
Sheng Wu Gong Cheng Xue Bao. 2010 Jul;26(7):880-7.
8
Recent Advances in the Microbial Synthesis of Hemoglobin.血红蛋白的微生物合成研究进展。
Trends Biotechnol. 2021 Mar;39(3):286-297. doi: 10.1016/j.tibtech.2020.08.004. Epub 2020 Sep 7.
9
Recent advances in synthetic biology for engineering isoprenoid production in yeast.酵母中用于工程化生产类异戊二烯的合成生物学最新进展。
Curr Opin Chem Biol. 2017 Oct;40:47-56. doi: 10.1016/j.cbpa.2017.05.017. Epub 2017 Jun 14.
10
Systems Metabolic Engineering Strategies: Integrating Systems and Synthetic Biology with Metabolic Engineering.系统代谢工程策略：系统生物学与合成生物学和代谢工程的整合。
Trends Biotechnol. 2019 Aug;37(8):817-837. doi: 10.1016/j.tibtech.2019.01.003. Epub 2019 Feb 5.
引用本文的文献
1
Scalable secondary metabolite production in Streptomyces using a plug-and-play system.利用即插即用系统在链霉菌中实现可扩展的次级代谢产物生产。
Nat Biotechnol. 2025 Aug 15. doi: 10.1038/s41587-025-02762-1.
2
Exploring pigment-producing Streptomyces as an alternative source to synthetic pigments: diversity, biosynthesis, and biotechnological applications. A review.探索产色素链霉菌作为合成色素的替代来源：多样性、生物合成及生物技术应用。综述
World J Microbiol Biotechnol. 2025 Jun 25;41(7):211. doi: 10.1007/s11274-025-04379-7.
3
Actinomycete-Derived Pigments: A Path Toward Sustainable Industrial Colorants.放线菌衍生色素：通往可持续工业色素的途径。
Mar Drugs. 2025 Jan 13;23(1):39. doi: 10.3390/md23010039.
4
Recent advances in the research of milbemycin biosynthesis and regulation as well as strategies for strain improvement.米尔贝霉素生物合成和调控研究进展及菌株改良策略。
Arch Microbiol. 2021 Dec;203(10):5849-5857. doi: 10.1007/s00203-021-02575-1. Epub 2021 Sep 22.
5
Integrating perspectives in actinomycete research: an ActinoBase review of 2020-21.整合放线菌研究视角：ActinoBase 对 2020-21 年的回顾。
Microbiology (Reading). 2021 Sep;167(9). doi: 10.1099/mic.0.001084.
本文引用的文献
1
DP4-AI automated NMR data analysis: straight from spectrometer to structure.DP4-AI自动化核磁共振数据分析：直接从光谱仪到结构
Chem Sci. 2020 Mar 6;11(17):4351-4359. doi: 10.1039/d0sc00442a.
2
Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture.通过共培养发现放线菌基因组中编码的新型次生代谢产物。
J Ind Microbiol Biotechnol. 2021 Jun 4;48(3-4). doi: 10.1093/jimb/kuaa001.
3
Investigation of the effects of actinorhodin biosynthetic gene cluster expression and a rpoB point mutation on the metabolome of Streptomyces coelicolor M1146.研究放线紫红素生物合成基因簇表达和 rpoB 点突变对变铅青链霉菌 M1146 代谢组的影响。
J Biosci Bioeng. 2021 May;131(5):525-536. doi: 10.1016/j.jbiosc.2021.01.002. Epub 2021 Feb 3.
4
Recent advances in heterologous expression of natural product biosynthetic gene clusters in Streptomyces hosts.天然产物生物合成基因簇在链霉菌宿主中的异源表达的最新进展。
Curr Opin Biotechnol. 2021 Jun;69:118-127. doi: 10.1016/j.copbio.2020.12.016. Epub 2021 Jan 11.
5
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in genomes.利用系统和合成生物学阐明基因组中编码的次生代谢物生物合成基因簇。
Nat Prod Rep. 2021 Jul 21;38(7):1330-1361. doi: 10.1039/d0np00071j.
6
Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in .环磷酸腺苷（cAMP）对[具体对象]中放线紫红素产生影响的多组学分析
Front Bioeng Biotechnol. 2020 Nov 5;8:595552. doi: 10.3389/fbioe.2020.595552. eCollection 2020.
7
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree.使用Qemistree对代谢组学质谱数据进行化学信息分析。
Nat Chem Biol. 2021 Feb;17(2):146-151. doi: 10.1038/s41589-020-00677-3. Epub 2020 Nov 16.
8
Enzyme-Constrained Models and Omics Analysis of Reveal Metabolic Changes that Enhance Heterologous Production.酶约束模型与组学分析揭示增强异源生产的代谢变化
iScience. 2020 Sep 3;23(9):101525. doi: 10.1016/j.isci.2020.101525. eCollection 2020 Sep 25.
9
An Update on Molecular Tools for Genetic Engineering of Actinomycetes-The Source of Important Antibiotics and Other Valuable Compounds.放线菌的基因工程分子工具最新进展——重要抗生素及其他有价值化合物的来源
Antibiotics (Basel). 2020 Aug 8;9(8):494. doi: 10.3390/antibiotics9080494.
10
Membrane transporters in the bioproduction of organic acids: state of the art and future perspectives for industrial applications.生物有机酸生产中的膜转运蛋白：工业应用的最新进展和未来展望。
FEMS Microbiol Lett. 2020 Aug 1;367(15). doi: 10.1093/femsle/fnaa118.
Zotero 插件