Department of Physiology, Faculty of Medicine, University of Kütahya Health Sciences, Kütahya, Turkey.
Department of Dermatology, Faculty of Medicine, University of Kütahya Health Sciences, Kütahya, Turkey.
J Cosmet Dermatol. 2022 Apr;21(4):1651-1655. doi: 10.1111/jocd.14264. Epub 2021 Jul 1.
Acne vulgaris (AV) is the most prevalent inflammatory skin disease and develops on the face and upper trunk. Resistin, a member of the cysteine-rich secretory proteins family, is an adipokine expressed primarily in macrophages and monocytes; it has a role to play in the inflammatory period.
This study's purpose was to detect whether known resistin gene (-420 C > G) polymorphism plays a role in the pathogenesis of AV.
Patients with AV (n = 94) and healthy controls (n = 94) were enrolled in this investigation. Resistin gene (-420 C > G) polymorphism was decided by PCR-RFLP procedure.
The distribution of genotype frequencies of resistin gene (-420 C > G) polymorphism was significantly different between the AV and healthy controls (p = 0.002). We found that the resistin gene (-420 C > G) CG genotype exhibited a significant association with decreased acne vulgaris risk.
Our study is the first report investigating the relationship between the risk of AV and resistin gene (-420 C > G) polymorphism in the Turkish population. Resistin gene (-420 C > G) polymorphism is related to AV pathogenesis. CG genotype has a protective role and may be linked to a reduced risk of AV development. Furthermore, studies are needed to verify these findings in other populations.
寻常痤疮（AV）是最常见的炎症性皮肤病，发生于面部和上半身。抵抗素是富含半胱氨酸的分泌蛋白家族的一员，主要在巨噬细胞和单核细胞中表达；它在炎症期发挥作用。
本研究旨在检测已知的抵抗素基因（-420C>G）多态性是否在 AV 的发病机制中起作用。
本研究纳入了 94 例 AV 患者和 94 例健康对照者。通过 PCR-RFLP 程序确定抵抗素基因（-420C>G）多态性。
抵抗素基因（-420C>G）多态性的基因型频率分布在 AV 组和健康对照组之间差异有统计学意义（p=0.002）。我们发现抵抗素基因（-420C>G）CG 基因型与降低寻常痤疮的发病风险显著相关。
本研究首次报告了在土耳其人群中，抵抗素基因（-420C>G）多态性与 AV 发病风险之间的关系。抵抗素基因（-420C>G）多态性与 AV 的发病机制有关。CG 基因型具有保护作用，可能与降低 AV 发病风险有关。此外，需要在其他人群中验证这些发现。
