与寻常痤疮相关的基因变异
Genetic Variants Associated with Acne Vulgaris.
作者信息
Zhang Huan, Zhang Zhengzhong
机构信息
Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, People's Republic of China.
出版信息
Int J Gen Med. 2023 Aug 28;16:3843-3856. doi: 10.2147/IJGM.S421835. eCollection 2023.
Acne vulgaris (AV) ranks among the common chronic inflammatory disorders that impact the sebaceous components of hair follicles. Acne vulgaris is characterised by cardinal manifestations such as the presence of pimples, nodules, pustules, and cysts, which have the potential to lead to the development of acne scarring and pigmentation. The phenomenon is influenced by polygenic inheritance or can be ascribed to the interplay between multiple genes and environmental factors. In recent years, some researchers have found that some genes (such as IL, TNF, RETN, CYP family, MMPs and TIMPs genes et al) are associated with acne vulgaris and may affect the progression and prognosis of the disease. The number of reviews addressing acne-associated genetic variants, however, is limited. In that case, we have compiled a list of prevalent genes associated with acne in recent times. This helps us understand acne's genetic basis and lets us step in early for people prone to severe acne, lowering the chance of acne scars.
寻常痤疮（AV）是常见的慢性炎症性疾病之一，会影响毛囊的皮脂腺成分。寻常痤疮的主要表现为丘疹、结节、脓疱和囊肿等，这些症状有可能导致痤疮瘢痕和色素沉着。这种现象受多基因遗传影响，也可归因于多个基因与环境因素之间的相互作用。近年来，一些研究人员发现某些基因（如白细胞介素、肿瘤坏死因子、视黄醇、细胞色素P450家族、基质金属蛋白酶和金属蛋白酶组织抑制因子基因等）与寻常痤疮有关，可能会影响该病的进展和预后。然而，针对痤疮相关基因变异的综述数量有限。在这种情况下，我们汇总了近期与痤疮相关的常见基因列表。这有助于我们了解痤疮的遗传基础，并让我们能够对易患重度痤疮的人群尽早进行干预，降低出现痤疮瘢痕的几率。
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