Ibrahim Latifat Bolanle, Idowu Patience Funmilayo, Mose S Opemipo Adekanye, Alabi Mutiu Adewunmi, Ajani Emmanuel Oladipo
Acta Chim Slov. 2021 Mar;68(1):127.
This study validates the antidiabetic efficacy of Enantia chlorantha stem bark and the possible therapeutic implications of the co-administration of lisinopril and E. chlorantha in type 2 diabetic rats. E. chlorantha stem bark was extracted by cold maceration. The inhibitory effect of the plant on carbohydrate metabolizing enzymes and its antioxidative potentials were assessed in vitro. The extract exhibited α-amylase and α-glucosidase inhibitory activities and also showed antioxidative properties in vitro. Administration of the extract normalized fasting hyperglycemia in vivo by showing 47.24 % reduction in blood glucose levels relative to untreated diabetic rats. Co-administration of E. chlorantha and lisinopril restored serum glucose and serum lipid profile levels. E. chlorantha stem bark displayed antidiabetic potentials as compared with a standard antidiabetic drug (metformin). The study also showed that the plant contained some bioactive compounds which we hypothesize might be responsible for the observed activities. Co-administration of the plant with lisinopril conferred no significant therapeutic advantage on the serum glucose level and lipid profile.
本研究验证了非洲臀果木茎皮的抗糖尿病功效以及赖诺普利与非洲臀果木联合给药对2型糖尿病大鼠可能的治疗意义。非洲臀果木茎皮采用冷浸法提取。在体外评估了该植物对碳水化合物代谢酶的抑制作用及其抗氧化潜力。提取物在体外表现出α -淀粉酶和α -葡萄糖苷酶抑制活性，还具有抗氧化特性。提取物给药后使体内空腹高血糖正常化，与未治疗的糖尿病大鼠相比，血糖水平降低了47.24%。非洲臀果木与赖诺普利联合给药可恢复血清葡萄糖和血清脂质水平。与标准抗糖尿病药物（二甲双胍）相比，非洲臀果木茎皮具有抗糖尿病潜力。该研究还表明，该植物含有一些生物活性化合物，我们推测这些化合物可能是观察到的活性的原因。该植物与赖诺普利联合给药在血清葡萄糖水平和脂质方面没有显著的治疗优势。
