Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
Institute of Gerontology & Department of Healthcare Sciences, Wayne State University, Detroit, Michigan, USA.
Alzheimers Dement. 2022 Jan;18(1):43-52. doi: 10.1002/alz.12381. Epub 2021 May 31.
Despite increased risk of cognitive decline in Hispanics/Latinos, research on early risk markers of Alzheimer's disease in this group is lacking. Subjective cognitive decline (SCD) may be an early risk marker of pathological aging. We investigated associations of SCD with objective cognition among a diverse sample of Hispanics/Latinos living in the United States.
SCD was measured with the Everyday Cognition Short Form (ECog-12) and cognitive performance with a standardized battery in 6125 adults aged ≥ 50 years without mild cognitive impairment or dementia (x̄ = 63.2 years, 54.5% women). Regression models interrogated associations of SCD with objective global, memory, and executive function scores.
Higher SCD was associated with lower objective global (B = -0.16, SE = 0.01), memory (B = -0.13, SE = 0.02), and executive (B = -0.13, SE = 0.02, p's < .001) function composite scores in fully adjusted models.
Self-reported SCD, using the ECog-12, may be an indicator of concurrent objective cognition in diverse middle-aged and older community-dwelling Hispanics/Latinos.
尽管西班牙裔/拉丁裔人群认知能力下降的风险增加，但针对该人群阿尔茨海默病早期风险标志物的研究却很少。主观认知下降（SCD）可能是病理性衰老的早期风险标志物。我们在一个居住在美国的不同西班牙裔/拉丁裔人群样本中研究了 SCD 与客观认知之间的关联。
使用 Everyday Cognition Short Form（ECog-12）测量 SCD，使用标准化电池测量认知表现，共有 6125 名年龄≥50 岁且无轻度认知障碍或痴呆的成年人参与（x̄=63.2 岁，54.5%为女性）。回归模型探究了 SCD 与客观整体、记忆和执行功能评分的关联。
在完全调整的模型中，较高的 SCD 与较低的客观整体（B=-0.16，SE=0.01）、记忆（B=-0.13，SE=0.02）和执行（B=-0.13，SE=0.02，p<0.001）功能复合评分相关。
使用 ECog-12 报告的 SCD 可能是不同年龄段和居住在社区中的中年西班牙裔/拉丁裔人群中当前客观认知的指标。
