Department of Clinical Sciences Malmö, Center for Primary Health Care Research, Lund University and Region Skåne, Malmö, Sweden.
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Addiction. 2021 Dec;116(12):3390-3397. doi: 10.1111/add.15591. Epub 2021 Jun 21.
Having a family member with an alcohol use disorder (AUD) may negatively affect a person's health. Our aim was to study the long-term risk of coronary heart disease (CHD) in parents who have an offspring with AUD.
Cohort study with Cox regression models and co-sibling analyses.
Sweden.
From population registers, we selected all parent-offspring pairs in which the parent was born in Sweden between 1945 and 1965.
Baseline was set when the offspring was 15 years old and AUD was assessed from medical and criminal registers. The parents were followed for CHD during a mean follow-up of 18 years. Hazard ratios (HRs) in mothers and fathers were calculated and adjusted for potential confounders (year of birth, age at childbirth, sex of the child, parent' AUD, educational level, and marital status).
In mothers, the adjusted HR for CHD was 1.24 (95% CI = 1.19-1.28) in relation to having a child with AUD. In fathers, the HR for CHD was lower than in mothers but still increased; the adjusted HR was 1.08 (95% CI = 1.05-1.12). In the co-sibling analyses, the HRs for mothers were similar to the HRs estimated from the population-based sample, but in fathers the association did not remain significant (HR = 0.98 [0.90-1.06]).
In Sweden, there appears to be an association between having an offspring with alcohol use disorder and increased risk of developing coronary heart disease. For fathers, the association did not remain in co-sibling analyses.
家庭成员患有酒精使用障碍（AUD）可能会对个人健康产生负面影响。我们的目的是研究父母一方有 AUD 子女的冠心病（CHD）长期风险。
队列研究，使用 Cox 回归模型和同卵双胞胎分析。
瑞典。
从人口登记册中，我们选择了所有父母-子女对，其中父母出生于 1945 年至 1965 年期间。
以子女 15 岁时为基线，通过医疗和刑事登记评估 AUD。父母在平均 18 年的随访期间随访 CHD。计算母亲和父亲的危险比（HR），并调整潜在混杂因素（出生年份、分娩年龄、子女性别、父母 AUD、教育水平和婚姻状况）。
在母亲中，与 AUD 子女有关的 CHD 调整后 HR 为 1.24（95%CI=1.19-1.28）。在父亲中，CHD 的 HR 低于母亲，但仍有上升趋势；调整后的 HR 为 1.08（95%CI=1.05-1.12）。在同卵双胞胎分析中，母亲的 HR 与基于人群样本估计的 HR 相似，但在父亲中，这种关联不再显著（HR=0.98[0.90-1.06]）。
在瑞典，AUD 子女与冠心病风险增加之间似乎存在关联。对于父亲来说，这种关联在同卵双胞胎分析中不再存在。
