粒细胞集落刺激因子作用于偏向淋巴系的短期造血干细胞。 - Suppr

Granulocyte colony-stimulating factor acts on lymphoid-biased, short-term hematopoietic stem cells.

作者信息

Chen Yulin, Rudolph K Lenhard

机构信息

Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Research Group on Stem Cell Aging, Jena and Medical Faculty, University Hospital Jena (UKJ), Jena.

出版信息

Haematologica. 2021 Jun 1;106(6):1516-1518. doi: 10.3324/haematol.2020.271205.

DOI:10.3324/haematol.2020.271205

PMID:34060296

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8168489/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39de/8168489/7f0fb2c18ef8/1061516.fig1.jpg

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Granulocyte colony-stimulating factor acts on lymphoid-biased, short-term hematopoietic stem cells.粒细胞集落刺激因子作用于偏向淋巴系的短期造血干细胞。

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MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1.MicroRNA126 通过降低血管细胞黏附分子 1 的表达促进粒细胞集落刺激因子诱导的造血祖细胞动员。

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Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells.硫酸乙酰肝素类似物可以有效地动员长期造血干细胞。

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Plerixafor and granulocyte colony-stimulating factor for first-line steady-state autologous peripheral blood stem cell mobilization in lymphoma and multiple myeloma: results of the prospective PREDICT trial.培洛昔福联合粒细胞集落刺激因子在淋巴瘤和多发性骨髓瘤一线稳定期自体外周血造血干细胞动员中的应用：前瞻性 PREDICT 试验结果。

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Progenipoietin-1: a multifunctional agonist of the granulocyte colony-stimulating factor receptor and fetal liver tyrosine kinase-3 is a potent mobilizer of hematopoietic stem cells.祖细胞生成素-1：粒细胞集落刺激因子受体和胎儿肝脏酪氨酸激酶-3的多功能激动剂，是造血干细胞的有效动员剂。

Exp Hematol. 2001 Aug;29(8):943-51. doi: 10.1016/s0301-472x(01)00675-0.

Long-Acting IL-33 Mobilizes High-Quality Hematopoietic Stem and Progenitor Cells More Efficiently Than Granulocyte Colony-Stimulating Factor or AMD3100.长效白细胞介素 33 比粒细胞集落刺激因子或 AMD3100 更有效地动员高质量造血干细胞和祖细胞。

Biol Blood Marrow Transplant. 2019 Aug;25(8):1475-1485. doi: 10.1016/j.bbmt.2019.05.030. Epub 2019 Jun 1.

Flt3 ligand synergizes with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice.Flt3配体与粒细胞-巨噬细胞集落刺激因子或粒细胞集落刺激因子协同作用，将造血祖细胞动员到小鼠外周血中。

Blood. 1997 Nov 1;90(9):3781-8.

Beyond CD34+ cell dose: impact of method of peripheral blood hematopoietic stem cell mobilization (granulocyte-colony-stimulating factor [G-CSF], G-CSF plus plerixafor, or cyclophosphamide G-CSF/granulocyte-macrophage [GM]-CSF) on number of colony-forming unit-GM, engraftment, and Day +100 hematopoietic graft function.超越 CD34+ 细胞剂量：外周血造血干细胞动员方法（粒细胞集落刺激因子[G-CSF]、G-CSF 加plerixafor 或环磷酰胺 G-CSF/粒细胞-巨噬细胞[GM]-CSF）对集落形成单位-GM 数量、植入和第 100 天造血移植物功能的影响。

Transfusion. 2011 Sep;51(9):1995-2000. doi: 10.1111/j.1537-2995.2011.03085.x. Epub 2011 Mar 10.

Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells.粒细胞集落刺激因子直接作用于小鼠偏向淋巴样的造血干细胞而非偏向髓样的造血干细胞。

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Peripheral blood stem cell mobilization from healthy donors.健康供体的外周血干细胞动员

Transfus Apher Sci. 2015 Aug;53(1):13-6. doi: 10.1016/j.transci.2015.05.008. Epub 2015 May 19.

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Survey of senescent cell markers with age in human tissues.人类组织中衰老细胞标志物随年龄变化的调查。

Aging (Albany NY). 2020 Mar 11;12(5):4052-4066. doi: 10.18632/aging.102903.

Haematologica. 2021 Jun 1;106(6):1647-1658. doi: 10.3324/haematol.2019.239251.

M-CSF improves protection against bacterial and fungal infections after hematopoietic stem/progenitor cell transplantation.巨噬细胞集落刺激因子可增强造血干细胞/祖细胞移植后对细菌和真菌感染的抵御能力。

J Exp Med. 2016 Oct 17;213(11):2269-2279. doi: 10.1084/jem.20151975. Epub 2016 Oct 10.

Per2 induction limits lymphoid-biased haematopoietic stem cells and lymphopoiesis in the context of DNA damage and ageing.PER2 诱导限制了 DNA 损伤和衰老背景下偏向淋巴细胞的造血干细胞和淋巴样生成。

Nat Cell Biol. 2016 May;18(5):480-90. doi: 10.1038/ncb3342. Epub 2016 Apr 18.

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.JAK抑制可减轻细胞衰老相关分泌表型及老年衰弱。

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. doi: 10.1073/pnas.1515386112. Epub 2015 Nov 2.

Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice.粒细胞集落刺激因子可使小鼠骨髓基质细胞重编程，从而积极抑制B淋巴细胞生成。

Blood. 2015 May 14;125(20):3114-7. doi: 10.1182/blood-2015-02-629444. Epub 2015 Mar 26.

B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2.B 细胞生成被动员剂量的 G-CSF 所阻断，并通过过度表达抗凋亡蛋白 Bcl2 得以挽救。

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Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP).NF-κB 信号通路在诱导衰老相关分泌表型（SASP）中的作用。

Cell Signal. 2012 Apr;24(4):835-45. doi: 10.1016/j.cellsig.2011.12.006. Epub 2011 Dec 11.

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.人类骨髓造血干细胞随着年龄的增长而频率增加，并偏向髓系。

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20012-7. doi: 10.1073/pnas.1116110108. Epub 2011 Nov 28.

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs.骨髓巨噬细胞维持造血干细胞（HSC）龛位，其耗竭可动员 HSCs。

Blood. 2010 Dec 2;116(23):4815-28. doi: 10.1182/blood-2009-11-253534. Epub 2010 Aug 16.

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Granulocyte colony-stimulating factor acts on lymphoid-biased, short-term hematopoietic stem cells.

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