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用于医疗应用和发展中国家假药分析/质量控制的毛细管电泳仪器。

Capillary Electrophoresis Instruments for Medical Applications and Falsified Drug Analysis/Quality Control in Developing Countries.

机构信息

Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CH-1211 Geneva 4, Switzerland.

出版信息

Anal Chem. 2021 Jun 15;93(23):8107-8115. doi: 10.1021/acs.analchem.1c00839. Epub 2021 Jun 1.

Abstract

The implementation of integrated analytical techniques to meet stringent requirements in the life sciences requires a well-developed analytical capacity. New technology in analytical equipment for the analysis of large and small molecules is continuously being developed. However, developing countries frequently struggle to keep pace with technological advancements. Hence, it is of utmost importance to better invest in optimizing existing and proven methodologies to tackle life-saving challenges in developing countries. In this regard, capillary electrophoresis is a promising candidate for solving multiple analytical problems compared to its chromatographic and spectroscopic counterparts due to its fast analytical response time and notable cost efficiency. In the following, we summarize various issues and opportunities for capillary electrophoresis to be the technique of choice for the unresolved bottlenecks in analytical equipment in developing countries for drug quality control. This perspective demonstrates that the ongoing quest for the design of new, impactful analytical techniques is a dynamic and rapidly developing research area and mentions some directions and opportunities that have arisen during the recent pandemic.

摘要

为满足生命科学领域的严格要求而实施综合分析技术,需要具备完善的分析能力。用于分析大、小分子的分析仪器的新技术正在不断发展。然而,发展中国家常常难以跟上技术进步的步伐。因此,至关重要的是,要更好地投资于优化现有的、经过验证的方法,以应对发展中国家的拯救生命的挑战。在这方面,与色谱和光谱相比,毛细管电泳由于其快速的分析响应时间和显著的成本效益,是解决多种分析问题的有前途的候选技术。在以下内容中,我们总结了各种问题和机遇,以证明毛细管电泳可以成为发展中国家解决药物质量控制分析仪器未决瓶颈的首选技术。这一观点表明,目前对设计新的、有影响力的分析技术的探索是一个充满活力和快速发展的研究领域,并提到了在最近的大流行期间出现的一些方向和机遇。

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