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组织配型在犬保留神经同种异体移植中的作用。

Role of tissue typing on preserved nerve allografts in dogs.

作者信息

Singh R, Mechelse K, Stefanko S

出版信息

J Neurol Neurosurg Psychiatry. 1977 Sep;40(9):865-71. doi: 10.1136/jnnp.40.9.865.

DOI:10.1136/jnnp.40.9.865
PMID:340618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC492859/
Abstract

Histocompatibility seems to play an important role in the regeneration of nerve allografts. Compatible tissue typed nerve allografts behave more like autografts and are, therefore, more readily accepted by the host tissue without producing evident tissue rejection. The influence of histocompatibility difference becomes more marked if the graft is longer than 30-40 mm. Irradiation as a means of reducing the immune reaction of the nerve allografts does not seem to have any beneficial effect along with tissue typing. Preservation of nerve grafts at - 70°C does not have any untoward effect.

摘要

组织相容性似乎在同种异体神经移植的再生中起着重要作用。组织类型相容的神经同种异体移植物的行为更类似于自体移植物,因此更容易被宿主组织接受,而不会产生明显的组织排斥反应。如果移植物长度超过30 - 40毫米,组织相容性差异的影响会更加明显。作为减少神经同种异体移植物免疫反应手段的辐照,似乎与组织分型一样没有任何有益效果。在-70°C下保存神经移植物没有任何不良影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eef/492859/2440480d757e/jnnpsyc00159-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eef/492859/2205d1b73ba7/jnnpsyc00159-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eef/492859/983f31f0c302/jnnpsyc00159-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eef/492859/bee94cfebe73/jnnpsyc00159-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eef/492859/2440480d757e/jnnpsyc00159-0036-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eef/492859/2205d1b73ba7/jnnpsyc00159-0035-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eef/492859/983f31f0c302/jnnpsyc00159-0035-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eef/492859/bee94cfebe73/jnnpsyc00159-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3eef/492859/2440480d757e/jnnpsyc00159-0036-b.jpg

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1
Role of tissue typing on preserved nerve allografts in dogs.组织配型在犬保留神经同种异体移植中的作用。
J Neurol Neurosurg Psychiatry. 1977 Sep;40(9):865-71. doi: 10.1136/jnnp.40.9.865.
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本文引用的文献

1
Recovery of fibre numbers and diameters in the regeneration of peripheral nerves.周围神经再生中纤维数量和直径的恢复
J Physiol. 1943 Mar 25;101(4):489-518. doi: 10.1113/jphysiol.1943.sp004002.
2
REGENERATION OF PERIPHERAL NERVES BY IRRADIATED HOMOGRAFTS.经辐照的同种异体移植物对周围神经的再生作用
J Bone Joint Surg Am. 1964 Mar;46:383-94.
3
Mechanism of rejection of peripheral nerve allografts.周围神经同种异体移植的排斥机制。
Surg Gynecol Obstet. 1967 Nov;125(5):1058-68.
4
Peripheral nerve grafts: experimental studies in the dog and chimpanzee to define homograft limitations.周围神经移植:在狗和黑猩猩身上进行的实验研究,以确定同种异体移植的局限性。
J Neurosurg. 1970 Feb;32(2):236-43. doi: 10.3171/jns.1970.32.2.0236.
5
The interfascicular nerve-grafting of the median and ulnar nerves.正中神经与尺神经的束间神经移植术。
J Bone Joint Surg Am. 1972 Jun;54(4):727-50.
6
Regeneration through peripheral nerve allografts. An electrophysiological and histological study following the use of immunosuppressive therapy.通过异体周围神经移植实现再生。使用免疫抑制疗法后的电生理和组织学研究。
Arch Neurol. 1973 Jan;28(1):31-7. doi: 10.1001/archneur.1973.00490190049005.