AMPK/mTOR 信号通路在二甲双胍抗癌活性中的作用。
The role of AMPK/mTOR signaling pathway in anticancer activity of metformin.
机构信息
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University Bratislava, Slovak Republic
出版信息
Physiol Res. 2021 Aug 31;70(4):501-508. doi: 10.33549/physiolres.934618. Epub 2021 Jun 1.
Abstract
Metformin (MTF) is a widely used drug for the treatment of diabetes mellitus type 2 (DM2) and frequently used as an adjuvant therapy for polycystic ovarian syndrome, metabolic syndrome, and in some cases also tuberculosis. Its protective effect on the cardiovascular system has also been described. Recently, MTF was subjected to various analyzes and studies that showed its beneficial effects in cancer treatment such as reducing cancer cell proliferation, reducing tumor growth, inducing apoptosis, reducing cancer risk in diabetic patients, or reducing likelihood of relapse. One of the MTF's mechanisms of action is the activation of adenosine-monophosphate-activated protein kinase (AMPK). Several studies have shown that AMPK/mammalian target of rapamycin (mTOR) pathway has anticancer effect in vivo and in vitro. The aim of this review is to present the anticancer activity of MTF highlighting the importance of the AMPK/mTOR pathway in the cancer process.
摘要
二甲双胍（MTF）是一种广泛用于治疗 2 型糖尿病（DM2）的药物，也常被用作多囊卵巢综合征、代谢综合征的辅助治疗药物，在某些情况下也用于治疗肺结核。它对心血管系统的保护作用也已被描述。最近，MTF 经历了各种分析和研究，表明其在癌症治疗中有多种有益作用，如减少癌细胞增殖、减少肿瘤生长、诱导细胞凋亡、降低糖尿病患者的癌症风险或降低癌症复发的可能性。MTF 的作用机制之一是激活腺苷一磷酸激活蛋白激酶（AMPK）。多项研究表明，AMPK/哺乳动物雷帕霉素靶蛋白（mTOR）通路在体内和体外均具有抗癌作用。本综述的目的是介绍 MTF 的抗癌活性，强调 AMPK/mTOR 通路在癌症进程中的重要性。
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