Clinic for General and Visceral Surgery, University of Ulm, Albert-Einstein Allee 23, Ulm, Germany.
Clinic for General and Visceral Surgery, University of Ulm, Ulm, Germany; Surgical and Asklepios Tumor Center (ATC), Asklepios Paulinen Klinik Wiesbaden, Richard Strauss-Str. 4, Wiesbaden, Germany.
Semin Cancer Biol. 2021 Nov;76:232-246. doi: 10.1016/j.semcancer.2021.05.030. Epub 2021 May 29.
The distinct biology of pancreatic cancer with aggressive and early invasive tumor cells, a tumor promoting microenvironment, late diagnosis, and high therapy resistance poses major challenges on clinicians, researchers, and patients. In current clinical practice, a curative approach for pancreatic cancer can only be offered to a minority of patients and even for those patients, the long-term outcome is grim. This bitter combination will eventually let pancreatic cancer rise to the second leading cause of cancer-related mortalities. With surgery being the only curative option, complete tumor resection still remains the center of pancreatic cancer treatment. In recent years, new developments in neoadjuvant and adjuvant treatment have emerged. Together with improved perioperative care including complication management, an increasing number of patients have become eligible for tumor resection. Basic research aims to further increase these numbers by new methods of early detection, better tumor modelling and personalized treatment options. This review aims to summarize the current knowledge on clinical and biologic features, surgical and non-surgical treatment options, and the improved collaboration of clinicians and basic researchers in pancreatic cancer that will hopefully result in more successful ways of curing pancreatic cancer.
胰腺癌具有侵袭性和早期浸润性肿瘤细胞、促进肿瘤生长的微环境、晚期诊断和高治疗抵抗性等独特生物学特性，这给临床医生、研究人员和患者带来了重大挑战。在当前的临床实践中，只有少数患者可以接受治愈性治疗，即使对于这些患者，长期预后也很严峻。这种痛苦的组合最终将使胰腺癌上升为癌症相关死亡的第二大主要原因。由于手术是唯一的治愈方法，因此完全肿瘤切除仍然是胰腺癌治疗的核心。近年来，新的辅助和辅助治疗方法不断涌现。随着包括并发症管理在内的围手术期护理的改善，越来越多的患者有资格接受肿瘤切除术。基础研究旨在通过早期检测、更好的肿瘤建模和个性化治疗方案等新方法，进一步增加这些患者的数量。本文旨在总结胰腺癌的临床和生物学特征、手术和非手术治疗选择以及临床医生和基础研究人员之间的合作的最新进展，希望能找到更有效的胰腺癌治疗方法。
