给线粒体撒盐：由NCLX介导的线粒体钠信号传导的代谢和病理生理作用
Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na signaling mediated by NCLX.
作者信息
Assali Essam A, Sekler Israel
机构信息
Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84105, Israel.
Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84105, Israel.
出版信息
Cell Calcium. 2021 May 19;97:102416. doi: 10.1016/j.ceca.2021.102416.
PMID:34062329
Abstract
NCLX, the mitochondrial Na/Ca transporter is a key player in Ca signaling. However, its role in Na signaling is poorly understood. In this review we focus on Na signaling by NCLX, and discuss recent physiological and pathophysiological roles attributed to the Na influx into mitochondria.
摘要
线粒体钠钙转运体NCLX是钙信号传导中的关键因子。然而，其在钠信号传导中的作用却鲜为人知。在本综述中，我们聚焦于NCLX介导的钠信号传导，并讨论了近期有关线粒体钠内流所赋予的生理和病理生理作用。
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