Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU).
Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU).
Dent Mater J. 2021 May 29;40(3):813-819. doi: 10.4012/dmj.2020-332. Epub 2021 Mar 27.
Poly(ether ether ketone) (PEEK) is a high-performance thermoplastic used for several industrial applications due to its excellent mechanical properties. However, the use of PEEK is limited to dental materials because of its poor implant-bone integration. In the present study, methylated polyrotaxanes (MePRXs) with 4-vinylbenzyl groups, which are supermolecules composed of methylated α-cyclodextrins and poly(ethylene glycol) chains end-capped with 4-vinylbenzyl groups, were covalently tethered onto PEEK surfaces using photo-induced polymerization to improve their osteoblast compatibility. The surface-tethering of MePRXs onto PEEK surfaces was confirmed by analyzing their attenuated total reflectance Fourier transform infrared spectra and contact angles. When mouse preosteoblasts were cultured on the MePRX-PEEK and bare PEEK surfaces, the MePRX-PEEK surfaces showed significantly better proliferation and osteoblast differentiation than the bare PEEK surfaces. These results suggest that surface modification of PEEKs using MePRXs improves their osteoblast compatibility.
聚醚醚酮（PEEK）是一种高性能热塑性塑料，由于其优异的机械性能，被用于多种工业应用。然而，由于其与植入物骨整合不良，PEEK 的使用仅限于牙科材料。在本研究中，使用了带有 4-乙烯基苄基的甲基化聚轮烷（MePRXs），其是由甲基化的α-环糊精和以 4-乙烯基苄基封端的聚乙二醇链组成的超分子，通过光引发聚合被共价键接到 PEEK 表面上，以提高其成骨细胞相容性。通过分析其衰减全反射傅里叶变换红外光谱和接触角，证实了 MePRXs 被接枝到 PEEK 表面上。当鼠前成骨细胞在 MePRX-PEEK 和裸 PEEK 表面上培养时，MePRX-PEEK 表面显示出比裸 PEEK 表面显著更好的增殖和成骨细胞分化。这些结果表明，使用 MePRXs 对 PEEK 进行表面改性可以提高其成骨细胞相容性。
