Lemoine Céline H, Nidom Reviany V, Ventura Roland, Indrasari Setyarina, Normalina Irine, Santoso Kuncoro Puguh, Derouet Francis, Barnier-Quer Christophe, Borchard Gerrit, Collin Nicolas, Nidom Chairul A
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1221 Geneva, Switzerland.
Vaccine Formulation Institute, Chemin des Aulx 14, 1228 Plan-les-Ouates, Switzerland.
Vaccines (Basel). 2021 May 5;9(5):461. doi: 10.3390/vaccines9050461.
Adequate global vaccine coverage during an influenza pandemic is essential to mitigate morbidity, mortality, and economic impact. Vaccine development and production needs to be sufficient to meet a vast global demand, requiring international cooperation and local vaccine production capacity, especially in resource-constrained countries. The use of adjuvants is one approach to augment the number of available vaccine doses and to overcome potential vaccine shortages. Appropriately selected adjuvant technologies can decrease the amount of vaccine antigen required per dose, may broaden or lengthen the conferred protection against disease, and may even allow protective single-dose vaccination. Here we describe a technology transfer collaboration between Switzerland and Indonesia that led to the establishment of a vaccine formulation platform in Surabaya which involved the transfer of equipment and expertise to enable research and development of adjuvanted vaccine formulations and delivery systems. This new Indonesian capability aims to facilitate local and regional access to know-how relating to adjuvanted vaccine formulations, thus promoting their application to local vaccine developers. In this review, we aim to share the "lessons learned" from this project to both support and inspire future scientific collaborations of a similar nature.
在流感大流行期间实现足够的全球疫苗接种覆盖率对于减轻发病率、死亡率和经济影响至关重要。疫苗的研发和生产需要足够满足全球巨大需求，这需要国际合作以及当地的疫苗生产能力，特别是在资源有限的国家。使用佐剂是增加可用疫苗剂量数量并克服潜在疫苗短缺的一种方法。适当选择的佐剂技术可以减少每剂所需的疫苗抗原量，可能拓宽或延长对疾病的保护作用，甚至可能实现单剂量疫苗接种产生保护效果。在此，我们描述了瑞士与印度尼西亚之间的一项技术转让合作，该合作促成了在泗水建立一个疫苗配方平台，其中涉及设备和专业知识的转让，以推动佐剂疫苗配方和递送系统的研发。印度尼西亚的这项新能力旨在促进当地和区域获取与佐剂疫苗配方相关的技术诀窍，从而推动其应用于当地疫苗研发人员。在本综述中，我们旨在分享该项目的“经验教训”，以支持和激励未来类似性质的科学合作。
